Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 7/20 | 0.59 |
| ▸ | CNR1 | P21554 | 3/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6098659 | 1.00 | CHRNA7 (0.59) | CHRNA7CNR1PRKAA2HSD11B1HTR7 | |
| SCHEMBL6098653 | 1.00 | CHRNA7 (0.59) | CHRNA7CNR1PRKAA2HSD11B1HTR7 | |
| SCHEMBL6099675 | 0.94 | CHRNA7 (0.51) | CHRNA7CNR1PRKAA2HSD11B1HTR7 | |
| SCHEMBL6101050 | 0.87 | CHRNA7 (0.58) | CHRNA7CNR1PRKAA2HSD11B1HTR7 | |
| SCHEMBL6101043 | 0.87 | CHRNA7 (0.58) | CHRNA7CNR1PRKAA2HSD11B1HTR7 | |
| SCHEMBL6100767 | 0.86 | CHRNA7 (0.59) | CHRNA7CNR1PRKAA2HSD11B1GRM5 | |
| SCHEMBL6100771 | 0.86 | CHRNA7 (0.59) | CHRNA7CNR1PRKAA2HSD11B1GRM5 | |
| SCHEMBL6631465 | 0.86 | CHRNA7 (0.59) | CHRNA7CNR1PRKAA2HSD11B1GRM5 | |
| SCHEMBL6632916 | 0.84 | CHRNA7 (0.55) | CHRNA7CNR1PRKAA2USP30 | |
| SCHEMBL6100212 | 0.84 | CHRNA7 (0.55) | CHRNA7CNR1PRKAA2USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478646-A1 | AZABICYCLIC COMPOUNDS WITH ALFA7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003072578-A1 | AZABICYCLIC COMPOUNDS WITH ALFA7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 2003-09-04 | — | — | WO | disclosed |