Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 11/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
| ▸ | AVPR1A | P37288 | 4/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5890845 | 0.94 | AVPR2 (0.46) | AVPR2ROCK2ROCK1AVPR1ACYP11B1 | |
| SCHEMBL5890712 | 0.93 | AVPR2 (0.48) | AVPR2ROCK2ROCK1AVPR1ACYP11B1 | |
| SCHEMBL5890756 | 0.91 | AVPR2 (0.45) | AVPR2ROCK2ROCK1AVPR1ACYP11B1 | |
| SCHEMBL5891111 | 0.91 | AVPR2 (0.48) | AVPR2ROCK2ROCK1AVPR1ACYP11B1 | |
| SCHEMBL5891337 | 0.90 | AVPR2 (0.44) | AVPR2ROCK2ROCK1AVPR1ACYP11B1 | |
| SCHEMBL5890931 | 0.89 | AVPR2 (0.45) | AVPR2ROCK2ROCK1AVPR1APDE4A | |
| SCHEMBL5890765 | 0.88 | AVPR2 (0.42) | AVPR2ROCK2ROCK1AVPR1APDE4A | |
| SCHEMBL5789141 | 0.87 | AVPR2 (0.57) | AVPR2ROCK2ROCK1AVPR1APDE4A | |
| SCHEMBL5891628 | 0.87 | AVPR1A (0.41) | AVPR2ROCK2ROCK1AVPR1ACYP11B1 | |
| SCHEMBL5891147 | 0.85 | AVPR1A (0.42) | AVPR2ROCK2AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377581-A1 | NOVEL TRICYCLIC PYRIDYL BENZAZEPINE CARBOXAMIDES AND DERIVATIVES THEREOF AS TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS | Wyeth (US) | 2004-01-07 | — | — | EP | disclosed |
| WO-2002083683-A1 | NOVEL TRICYCLIC PYRIDYL BENZAZEPINE CARBOXAMIDES AND DERIVATIVES THEREOF TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS | WYETH (US) | 2002-10-24 | — | — | WO | disclosed |