Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.79 |
| ▸ | MAPT | P10636 | 5/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.53 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MPI | P34949 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11401029 | 0.92 | POLB (0.73) | POLBMAPTALDH1A1KDM4ETSHR | |
| SCHEMBL177812 | 0.88 | POLB (1.00) | POLBMAPTALDH1A1KDM4ETSHR | |
| SCHEMBL3292782 | 0.87 | TSHR (0.75) | POLBALDH1A1TSHRLOXL2KCNJ1 | |
| SCHEMBL2356855 | 0.83 | POLB (0.71) | POLBMAPTALDH1A1KDM4EKMT2A | |
| Perchlorate SCHEMBL11651402 | 0.82 | POLB (0.86) | POLBMAPTALDH1A1KDM4ETSHR | |
| SCHEMBL27404099 | 0.82 | POLB (0.86) | POLBMAPTALDH1A1KDM4ETSHR | |
| SCHEMBL8622580 | 0.81 | MAPT (0.61) | POLBMAPTALDH1A1KDM4ECYP19A1 | |
| SCHEMBL2352042 | 0.81 | NPC1 (0.65) | POLBMAPTALDH1A1KDM4ETSHR | |
| SCHEMBL2352643 | 0.81 | POLB (1.00) | POLBMAPTALDH1A1KDM4ETSHR | |
| SCHEMBL3257916 | 0.81 | POLB (0.58) | POLBMAPTALDH1A1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104424-B1 | PROCESS FOR THE SYNTHESIS OF CARBAPENEM INTERMEDIATES | MERCK & CO INC (US) | 2004-04-07 | — | — | EP | claimed |