Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6629286 | 0.81 | NPC1 (0.53) | NPC1RAB9AGAAMAPK1SMN1; SMN2 | |
| SCHEMBL2756575 | 0.77 | RAB9A (0.67) | NPC1RAB9AGAAMAPK1SMN1; SMN2 | |
| SCHEMBL10271315 | 0.77 | RAB9A (0.66) | NPC1RAB9AGAAMAPK1SMN1; SMN2 | |
| SCHEMBL16615785 | 0.77 | SMN1; SMN2 (0.58) | NPC1RAB9AGAAKEAP1SMN1; SMN2 | |
| SCHEMBL5358557 | 0.76 | NPC1 (0.63) | NPC1RAB9AGAAMAPK1SMN1; SMN2 | |
| SCHEMBL13462723 | 0.76 | RAB9A (0.63) | NPC1RAB9AGAAMAPK1SMN1; SMN2 | |
| SCHEMBL6630285 | 0.76 | NPC1 (0.63) | NPC1RAB9AGAAMAPK1SMN1; SMN2 | |
| SCHEMBL10047756 | 0.76 | NPC1 (0.63) | NPC1RAB9AGAAMAPK1KEAP1 | |
| SCHEMBL1913966 | 0.76 | KCNH2 (0.64) | NPC1RAB9AGAAKEAP1SMN1; SMN2 | |
| SCHEMBL11293396 | 0.76 | GAA (0.63) | NPC1RAB9AGAAMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1394162-A1 | Intermediates of azole antifungal agents and processes for the preparation thereof | Eisai Co., Ltd. (JP) | 2004-03-03 | — | — | EP | disclosed |
| EP-1394142-A1 | Carboxylic acid intermediates of antifungal agents and processes for the preparation thereof | Eisai Co., Ltd. (JP) | 2004-03-03 | — | — | EP | disclosed |
| CN-1478778-A | Antifungal agent and its preparation method and intermediate | ������������ʽ���� | 2004-03-03 | — | — | CN | disclosed |
| CN-1134421-C | Antifungal agent, and preparation method and intermediate thereof | ʷ��˿�������ȳ�ķ����˾ | 2004-01-14 | — | — | CN | disclosed |
| CN-1121404-C | Antifungal agent, and preparation method and intermediate thereof | EISAI CO LTD (JP) | 2003-09-17 | — | — | CN | disclosed |
| EP-1231210-A2 | Azole antifungal agents, processes for the preparation thereof, and intermediates | Eisai Co., Ltd. (JP) | 2002-08-14 | — | — | EP | disclosed |
| CN-1320597-A | Antifungal agent, and preparation method and intermediate thereof | EISAI CO LTD (JP) | 2001-11-07 | — | — | CN | disclosed |
| CN-1061347-C | Antifungal agent and its preparation method and intermediate | EISAI CO LTD (JP) | 2001-01-31 | — | — | CN | disclosed |
| CN-1045441-C | Antifungal agent, and preparation method and intermediate thereof | EISAI CO LTD (JP) | 1999-10-06 | — | — | CN | disclosed |
| CN-1226555-A | Antifungal agent, and preparation method and intermediate thereof | — | 1999-08-25 | — | — | CN | disclosed |
| CN-1219538-A | Antifungal agent, and preparation method and intermediate thereof | EISAI CO LTD (JP) | 1999-06-16 | — | — | CN | disclosed |
| US-5792781-A | EFFECTIVE AGAINST DERMATOMYCOSIS/VISCEROMYCOSIS CAUSED BY FUNGI, I.E., CANDIDA ALBICANS | EISAI CO., LTD. (JP) | 1998-08-11 | — | — | US | disclosed |
| US-5789429-A | FUNGICIDE | EISAI CO., LTD. (JP) | 1998-08-04 | — | — | US | disclosed |
| CN-1188765-A | Antifungal agent and its preparation method and intermediate | EISAI CO LTD (JP) | 1998-07-29 | — | — | CN | disclosed |
| US-5648372-A | TRIAZOLES | EISAI CO., LTD. (JP) | 1997-07-15 | — | — | US | disclosed |
| CN-1113241-A | Antifungal agent, and preparation method and intermediate thereof | EISAI CO LTD (JP) | 1995-12-13 | — | — | CN | disclosed |
| EP-0667346-A2 | Azole antifungal agents, process for the preparation there of and intermediates | Eisai Co., Ltd. (JP) | 1995-08-16 | — | — | EP | disclosed |