Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SCD | O00767 | 1/20 | 0.37 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.37 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4055320 | 0.81 | CYP2D6 (0.54) | TSHRCYP2D6SLC6A2SLC6A4CYP3A4 | |
| SCHEMBL6323564 | 0.81 | CYP2D6 (0.54) | TSHRCYP2D6SLC6A2SLC6A4CYP3A4 | |
| SCHEMBL1205146 | 0.81 | CYP2D6 (0.54) | TSHRCYP2D6SLC6A2SLC6A4CYP3A4 | |
| Hydrochloric Acid SCHEMBL6668150 | 0.79 | CYP2D6 (0.52) | TSHRCYP2D6SLC6A2SLC6A4CYP3A4 | |
| Hydrochloric Acid SCHEMBL6282414 | 0.79 | CYP2D6 (0.52) | TSHRCYP2D6SLC6A2SLC6A4CYP3A4 | |
| SCHEMBL23366934 | 0.79 | CYP2D6 (0.45) | TSHRCYP2D6SLC6A2SLC6A4CYP3A4 | |
| SCHEMBL10891883 | 0.78 | HIF1A (0.50) | TSHRCYP2D6CYP3A4KCNA5KDM4E | |
| SCHEMBL7040753 | 0.78 | KDM4E (0.46) | TSHRCYP2D6SLC6A2SLC6A4CYP3A4 | |
| SCHEMBL22480688 | 0.77 | ADRB2 (0.58) | TSHRCYP2D6CYP3A4KDM4EKMT2A | |
| SCHEMBL23371340 | 0.77 | TSHR (0.41) | TSHRCYP2D6SLC6A2SLC6A4CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1472260-A2 | THIENO(3,2-B)PYRIDONES AS ANTIVIRAL COMPOUNDS | PHARMACIA & UPJOHN COMPANY (US) | 2004-11-03 | — | — | EP | claimed |
| WO-2003059878-A2 | THIENO (3, 2-B) PYRIDONES AS ANTIVIRAL COMPOUNDS | PHARMACIA & UPJOHN COMPANY (US) | 2003-07-24 | — | — | WO | claimed |