Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | TTR | P02766 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4851764 | 0.96 | NPC1 (0.56) | NPC1TTRACHETDP1RAD52 | |
| Oxalic Acid SCHEMBL4860550 | 0.96 | NPC1 (0.53) | NPC1TTRACHETDP1RAD52 | |
| Hydrochloric Acid SCHEMBL4853072 | 0.96 | NPC1 (0.55) | NPC1TTRACHETDP1RAD52 | |
| Bromide SCHEMBL4862987 | 0.96 | NPC1 (0.55) | NPC1TTRACHETDP1RAD52 | |
| SCHEMBL6035877 | 0.96 | NPC1 (0.55) | NPC1TTRACHETDP1RAD52 | |
| Hydrochloric Acid SCHEMBL4860319 | 0.95 | NPC1 (0.54) | NPC1TTRACHETDP1RAD52 | |
| Sulfuric Acid SCHEMBL4858850 | 0.94 | NPC1 (0.53) | NPC1TTRACHETDP1RAD52 | |
| SCHEMBL13987325 | 0.92 | ACHE (0.51) | NPC1TTRACHE | |
| SCHEMBL13987339 | 0.91 | ACHE (0.50) | NPC1TTRACHE | |
| Citric Acid SCHEMBL4860949 | 0.91 | NPC1 (0.47) | NPC1TTRACHERAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1466625-A1 | PREVENTIVES/REMEDIES FOR URINARY DISTURBANCE | Takeda Chemical Industries, Ltd. (JP) | 2004-10-13 | — | — | EP | disclosed |