Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30598373 | 0.86 | POLB (0.32) | POLB | |
| SCHEMBL26112979 | 0.84 | POLB (0.31) | POLB | |
| SCHEMBL15845781 | 0.72 | POLB (0.31) | POLB | |
| SCHEMBL791978 | 0.71 | PDE10A (0.41) | POLB | |
| SCHEMBL26113843 | 0.69 | PDE10A (0.40) | POLB | |
| Hydrochloric Acid SCHEMBL5012070 | 0.69 | CYP1A2 (0.42) | LMNA | |
| Hydrochloric Acid SCHEMBL14119535 | 0.69 | CYP1A2 (0.42) | LMNA | |
| SCHEMBL20439958 | 0.67 | — | — | |
| SCHEMBL9642713 | 0.67 | L3MBTL1 (0.40) | POLBLMNA | |
| SCHEMBL16781846 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0964860-B1 | ATROPISOMERS OF 3-HETEROARYL-4(3H)-QUINAZOLINONES FOR THE TREATMENT OF NEURODEGENERATIVE AND CNS-TRAUMA RELATED CONDITIONS | PFIZER PROD INC (US) | 2004-04-21 | — | — | EP | disclosed |
| EP-0968194-A1 | ATROPISOMERS OF 3-ARYL-4(3H)-QUINAZOLINONES AND THEIR USE AS AMPA-RECEPTOR ANTAGONISTS | Pfizer Products Inc. (US) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998038173-A1 | ATROPISOMERS OF 3-ARYL-4(3H)-QUINAZOLINONES AND THEIR USE AS AMPA-RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 1998-09-03 | — | — | WO | disclosed |