Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.53 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CFD | P00746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6634565 | 0.88 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DSIRT2 | |
| SCHEMBL6632923 | 0.86 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DSIRT2 | |
| SCHEMBL6680403 | 0.86 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL5778750 | 0.85 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6633838 | 0.85 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DSIRT2 | |
| SCHEMBL6633231 | 0.85 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DL3MBTL1 | |
| SCHEMBL5775465 | 0.84 | SLC40A1 (0.48) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6636888 | 0.84 | KDM4A (0.51) | PDE4APDE4BPDE4CPDE4DHTT | |
| SCHEMBL6633839 | 0.84 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL6633023 | 0.84 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DSIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487797-A1 | HETERO-BRIDGE SUBSTITUTED 8-ARYLQUINOLINE PDE4 INHIBITORS | Merck Frosst Canada & Co. (CA) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003078397-A1 | HETERO-BRIDGE SUBSTITUTED 8-ARYLQUINOLINE PDE4 INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2003-09-25 | — | — | WO | disclosed |