Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 6/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5107405 | 0.81 | HRH3 (0.64) | KMT2AHRH3ACHE | |
| SCHEMBL14287678 | 0.80 | HRH3 (0.68) | KMT2AHRH3ACHE | |
| SCHEMBL14287660 | 0.80 | HRH3 (0.68) | KMT2AHRH3ACHE | |
| SCHEMBL5100294 | 0.79 | KMT2A (0.59) | KMT2AHRH3ACHEDPP7LTA4H | |
| SCHEMBL6630944 | 0.78 | HRH3 (0.44) | KMT2AHRH3LTA4HCYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL6635326 | 0.77 | HRH3 (0.43) | KMT2AHRH3LTA4HCYP3A4CYP2D6 | |
| SCHEMBL4088664 | 0.77 | HRH3 (0.70) | ITGB3ITGA2BHRH3ACHE | |
| SCHEMBL14287674 | 0.75 | HRH3 (0.68) | HRH3ACHE | |
| SCHEMBL23710932 | 0.74 | KMT2A (0.48) | KMT2AHRH3ACHELTA4HCYP2D6 | |
| SCHEMBL5097548 | 0.74 | HRH3 (0.71) | KMT2AHRH3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379493-A2 | NON-IMIDAZOLE ARYL ALKYLAMINES COMPOUNDS AS HISTAMINE H3 RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | Eli Lilly and Company (US) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002076925-A2 | NON-IMIDAZOLE ARYL ALKYLAMINES COMPOUNDS AS HISTAMINE H3 RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2002-10-03 | — | — | WO | disclosed |