Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | POLB | P06746 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | IDO1 | P14902 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10424594 | 0.84 | ALDH1A1 (0.73) | ALDH1A1POLBMAPTKMT2ANPC1 | |
| SCHEMBL27693699 | 0.83 | ALDH1A1 (0.66) | ALDH1A1POLBMAPTKMT2ANPC1 | |
| SCHEMBL5809526 | 0.83 | ALDH1A1 (1.00) | ALDH1A1POLBMAPTKMT2ANPC1 | |
| SCHEMBL2310273 | 0.81 | ALDH1A1 (0.68) | ALDH1A1POLBMAPTKMT2ANPC1 | |
| SCHEMBL11146599 | 0.81 | ALDH1A1 (0.96) | ALDH1A1POLBMAPTKMT2ANPC1 | |
| SCHEMBL27411500 | 0.80 | KMT2A (0.61) | ALDH1A1POLBMAPTKMT2ANPC1 | |
| SCHEMBL11497918 | 0.79 | ALDH1A1 (0.65) | ALDH1A1POLBMAPTKMT2ANPC1 | |
| SCHEMBL27556286 | 0.79 | ALDH1A1 (0.66) | ALDH1A1POLBMAPTKMT2ANPC1 | |
| SCHEMBL13479831 | 0.79 | ALDH1A1 (0.66) | ALDH1A1POLBMAPTKMT2ANPC1 | |
| SCHEMBL2312672 | 0.78 | ALDH1A1 (0.63) | ALDH1A1POLBMAPTKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934303-B1 | COMPOUNDS USEFUL FOR INHIBITION OF FARNESYL PROTEIN TRANSFERASE | SCHERING CORP (US) | 2004-12-29 | — | — | EP | disclosed |
| EP-0927178-B1 | TRICYCLIC COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES | SCHERING CORP (US) | 2002-02-27 | — | — | EP | disclosed |
| US-5958890-A | ANTITUMOR | SCHERING CORPORATION (US) | 1999-09-28 | — | — | US | disclosed |
| EP-0934303-A2 | COMPOUNDS USEFUL FOR INHIBITION OF FARNESYL PROTEIN TRANSFERASE | SCHERING CORPORATION (US) | 1999-08-11 | — | — | EP | disclosed |
| US-5861395-A | ENZYME INHIBITORS FOR BREAST TUMOR CELLS | SCHERING CORPORATION (US) | 1999-01-19 | — | — | US | disclosed |
| WO-1998011091-A2 | TRICYCLIC COMPOUNDS USEFUL FOR INHIBITION OF FARNESYL PROTEIN TRANSFERASE | SCHERING CORPORATION (US) | 1998-03-19 | — | — | WO | disclosed |