Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 8/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.31 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HPGDS | O60760 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6099174 | 1.00 | CHRNA7 (0.48) | CHRNA7USP30BRD4PAK1CNR2 | |
| SCHEMBL6099170 | 1.00 | CHRNA7 (0.48) | CHRNA7USP30BRD4PAK1CNR2 | |
| SCHEMBL6099627 | 0.94 | CHRNA7 (0.41) | CHRNA7USP30BRD4CNR2ACKR3 | |
| SCHEMBL6636524 | 0.88 | CHRNA7 (0.51) | CHRNA7USP30KMT2A | |
| SCHEMBL6100591 | 0.88 | CHRNA7 (0.51) | CHRNA7USP30KMT2A | |
| SCHEMBL6100593 | 0.88 | CHRNA7 (0.51) | CHRNA7USP30KMT2A | |
| SCHEMBL6634932 | 0.85 | CHRNA7 (0.48) | CHRNA7USP30 | |
| SCHEMBL6099035 | 0.85 | CHRNA7 (0.48) | CHRNA7USP30 | |
| SCHEMBL6099045 | 0.85 | CHRNA7 (0.48) | CHRNA7USP30 | |
| SCHEMBL6635522 | 0.84 | CHRNA7 (0.54) | CHRNA7USP30BRD4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478646-A1 | AZABICYCLIC COMPOUNDS WITH ALFA7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003072578-A1 | AZABICYCLIC COMPOUNDS WITH ALFA7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 2003-09-04 | — | — | WO | disclosed |