Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 8/20 | 0.44 |
| ▸ | F10 | P00742 | 11/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6637038 | 0.94 | F2 (0.49) | F2F10MAPTNPSR1NPC1 | |
| SCHEMBL6640166 | 0.91 | F2 (0.42) | F2F10MAPTNPSR1NPC1 | |
| SCHEMBL6634421 | 0.89 | HCRTR2 (0.39) | MAPTNPSR1NPC1NLRP3 | |
| SCHEMBL6634703 | 0.86 | F2 (0.53) | F2F10 | |
| SCHEMBL6635194 | 0.85 | F2 (0.39) | F2F10NPSR1 | |
| SCHEMBL6636381 | 0.85 | F2 (0.47) | F2F10MAPTNPSR1NPC1 | |
| Hydrochloric Acid SCHEMBL8032330 | 0.84 | F2 (0.57) | F2F10 | |
| SCHEMBL6636049 | 0.83 | F2 (0.57) | F2F10PDE10AITGB3ITGA2B | |
| SCHEMBL6642043 | 0.83 | F2 (0.47) | F2F10PDE10A | |
| SCHEMBL6639197 | 0.83 | MAPT (0.42) | F2MAPTNPSR1NPC1NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100795-B1 | DISUBSTITUTED BICYCLIC HETEROCYCLES HAVING, IN PARTICULAR, A THROMBIN INHIBITIVE EFFECT | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-06-09 | — | — | EP | disclosed |
| US-6121308-A | INDOLE AND BENZIMIDAZOLE ANTITHROMBOTIC COMPOUNDS, SUCH AS 1-METHYL-2-(N-(4-AMIDINOPHENYL)-AMINOMETHYL)-5-(N-(HYDROXYCARBONYLMETHYL) -QUINOLINE-8-SULPHONYLAMINO)-INDOLE | BOEHRINGER INGELHEIM KG (DE) | 2000-09-19 | — | — | US | disclosed |