Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6638190 | 0.86 | MAPT (0.58) | MAPTSMN1; SMN2KMT2AMEN1NPSR1 | |
| SCHEMBL8139587 | 0.83 | MAPT (0.55) | MAPTSMN1; SMN2KMT2AMEN1NPSR1 | |
| SCHEMBL10642774 | 0.80 | MAPT (0.60) | MAPTSMN1; SMN2KMT2AMEN1NPSR1 | |
| SCHEMBL10642324 | 0.80 | MAPT (0.60) | MAPTSMN1; SMN2KMT2AMEN1NPSR1 | |
| SCHEMBL490191 | 0.78 | KMT2A (0.47) | SMN1; SMN2KMT2AMEN1LMNAPOLB | |
| SCHEMBL6637294 | 0.77 | CYP1A2 (0.56) | SMN1; SMN2KMT2AMEN1LMNAL3MBTL1 | |
| SCHEMBL490003 | 0.77 | MEN1 (0.59) | MAPTSMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL490086 | 0.76 | MPO (0.48) | SMN1; SMN2KMT2AMEN1NPSR1POLB | |
| SCHEMBL6641351 | 0.76 | SMN1; SMN2 (0.56) | MAPTSMN1; SMN2KMT2AMEN1NPSR1 | |
| SCHEMBL1520900 | 0.75 | MPO (0.54) | MAPTSMN1; SMN2KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1449835-A2 | Alpha-substituted pyrimidine-thioalkyl and alkylether compounds | PHARMACIA & UPJOHN COMPANY (US) | 2004-08-25 | — | — | EP | disclosed |
| EP-1247804-A1 | Pyrimidine-thioalkyl and alkylether compounds | PHARMACIA & UPJOHN COMPANY (US) | 2002-10-09 | — | — | EP | disclosed |