Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.62 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.51 |
| ▸ | RARB | P10826 | 6/20 | 0.50 |
| ▸ | RARA | P10276 | 4/20 | 0.43 |
| ▸ | RARG | P13631 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.43 |
| ▸ | GOT1 | P17174 | 1/20 | 0.43 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL404926 | 1.00 | HDAC11 (0.62) | HDAC11HDAC2HDAC7HDAC8HDAC6 | |
| SCHEMBL29462773 | 0.88 | HDAC11 (0.49) | HDAC11HDAC2HDAC7HDAC8HDAC6 | |
| SCHEMBL10046516 | 0.86 | HDAC11 (0.55) | HDAC11HDAC2HDAC7HDAC8HDAC6 | |
| SCHEMBL405445 | 0.86 | HDAC11 (0.82) | HDAC11HDAC2HDAC7HDAC8HDAC6 | |
| SCHEMBL405444 | 0.86 | HDAC11 (0.82) | HDAC11HDAC2HDAC7HDAC8HDAC6 | |
| SCHEMBL29462871 | 0.86 | HDAC11 (0.47) | HDAC11HDAC2HDAC7HDAC8HDAC6 | |
| SCHEMBL29462770 | 0.84 | HDAC11 (0.46) | HDAC11HDAC2HDAC7HDAC8HDAC6 | |
| SCHEMBL404472 | 0.84 | HDAC11 (0.49) | HDAC11HDAC2HDAC7HDAC8HDAC6 | |
| SCHEMBL399513 | 0.82 | HDAC11 (0.47) | HDAC11HDAC2HDAC7HDAC8HDAC6 | |
| SCHEMBL30015366 | 0.81 | HDAC11 (0.74) | HDAC11HDAC2HDAC7HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412317-A1 | RETINOID DERIVATIVES WITH ANTIANGIOGENIC, ANTITUMOR AND PROAPOPTOTIC ACTIVITIES | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003011808-A1 | RETINOID DERIVATIVES WITH ANTIANGIOGENIC, ANTITUMORAL AND PROAPOPTOTIC ACTIVITIES | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2003-02-13 | — | — | WO | disclosed |