SCHEMBL6636271

SCHEMBL6636271

COC(COCc1cccc([N+](=O)[O-])c1)OC

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.51
MAOB P27338 3/20 0.50
MAOA P21397 1/20 0.50
CYP2D6 P10635 2/20 0.47
CYP2C9 P11712 2/20 0.47
CYP2C19 P33261 2/20 0.47
RECQL P46063 1/20 0.47
MEN1 O00255 3/20 0.46
KMT2A Q03164 3/20 0.46
HSP90AA1 P07900 1/20 0.46
LMNA P02545 1/20 0.46
CYP1A2 P05177 1/20 0.46
MAPT P10636 3/20 0.45
ALDH1A1 P00352 2/20 0.45
KDM4E B2RXH2 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
CA12 O43570 1/20 0.44
FFAR1 O14842 1/20 0.44
POLB P06746 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1767329 0.84 TSHR (0.65) TSHRMAOBMAOACYP2D6CYP2C9
SCHEMBL9506289 0.83 TSHR (0.49) TSHRMAOBMAOACYP2D6CYP2C9
SCHEMBL3721964 0.81 TSHR (0.57) TSHRMAOBMAOACYP2D6CYP2C9
SCHEMBL8673409 0.80 TSHR (0.49) TSHRMAOBMAOACYP2D6CYP2C9
SCHEMBL7861196 0.80 TSHR (0.59) TSHRMAOBMAOACYP2D6CYP2C9
SCHEMBL791926 0.79 TSHR (0.62) TSHRMAOBMAOACYP2D6CYP2C9
SCHEMBL4735452 0.79 TSHR (0.54) TSHRMAOBMAOACYP2D6CYP2C9
SCHEMBL30041959 0.79 TSHR (0.54) TSHRMAOBMAOACYP2D6CYP2C9
SCHEMBL8260909 0.79 TSHR (0.54) TSHRMAOBMAOACYP2D6CYP2C9
SCHEMBL18714233 0.78 TSHR (0.57) TSHRMAOBMAOAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1487822-A2 PYRROLE-2,5-DIONE DERIVATIVES AND THEIR USE AS GSK-3 INHIBITORS ELI LILLY AND COMPANY (US) 2004-12-22 EP disclosed
EP-1483265-A1 PURINE DERIVATIVES AS KINASE INHIBITORS ELI LILLY AND COMPANY (US) 2004-12-08 EP disclosed
WO-2003076442-A1 PURINE DERIVATIVES AS KINASE INHIBITORS ELI LILLY AND COMPANY (US) 2003-09-18 WO disclosed
WO-2003076398-A2 PYRROLE-2, 5-DIONE DERIVATIVES AND THEIR USE AS GSK-3 INHIBITORS ELI LILLY AND COMPANY (US) 2003-09-18 WO disclosed