SCHEMBL6637055

SCHEMBL6637055

CCN(CC)c1cc(N)nc(SCc2ccccc2)n1

nearest known ligand 0.68

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 6/20 0.68
NPC1 O15118 2/20 0.68
SMN1; SMN2 Q16637 2/20 0.68
HSP90AA1 P07900 1/20 0.50
MEN1 O00255 1/20 0.49
KMT2A Q03164 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.46
HSD17B10 Q99714 1/20 0.45
ALOX15 P16050 1/20 0.44
TP53 P04637 1/20 0.44
SCN9A Q15858 1/20 0.44
PAK4 O96013 1/20 0.43
CXCR2 P25025 1/20 0.42
CTSB P07858 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10882423 0.82 RAB9A (1.00) RAB9ANPC1SMN1; SMN2HSP90AA1MEN1
SCHEMBL1520825 0.78 RAB9A (0.78) RAB9ANPC1SMN1; SMN2HSP90AA1MEN1
SCHEMBL8138707 0.75 RAB9A (0.73) RAB9ANPC1SMN1; SMN2HSP90AA1MEN1
SCHEMBL489860 0.75 RAB9A (0.78) RAB9ANPC1SMN1; SMN2HSP90AA1MEN1
SCHEMBL1520770 0.75 RAB9A (0.78) RAB9ANPC1SMN1; SMN2HSP90AA1MEN1
SCHEMBL114060 0.72 RAB9A (0.62) RAB9ANPC1SMN1; SMN2HSP90AA1MEN1
SCHEMBL13752162 0.71 RAB9A (0.70) RAB9ANPC1SMN1; SMN2HSP90AA1L3MBTL1
SCHEMBL20635469 0.70 HTT (0.53) RAB9ANPC1SMN1; SMN2HSP90AA1KMT2A
SCHEMBL5450296 0.69 RAB9A (0.68) RAB9ANPC1SMN1; SMN2HSP90AA1MEN1
SCHEMBL6640402 0.68 HSD17B10 (0.70) RAB9ANPC1SMN1; SMN2HSP90AA1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1449835-A2 Alpha-substituted pyrimidine-thioalkyl and alkylether compounds PHARMACIA & UPJOHN COMPANY (US) 2004-08-25 EP disclosed
EP-1247804-A1 Pyrimidine-thioalkyl and alkylether compounds PHARMACIA & UPJOHN COMPANY (US) 2002-10-09 EP disclosed
US-6124306-A Thioalkyl alpha substituted pyrimidine compounds PHARMACIA & UPJOHN COMPANY (US) 2000-09-26 US disclosed
EP-1034167-A1 ALPHA-ALKYLTHIO SUBSTITUTED PYRIMIDINE ETHERS AND THIOETHERS AS VIRAL REVERSE TRANSCRIPTASE INHIBITORS PHARMACIA & UPJOHN COMPANY (US) 2000-09-13 EP disclosed
US-6043248-A VIRICIDES FOR TREATING AN INDIVIDUAL INFECTED WITH THE HUMAN IMMUNODEFICIENCY VIRUS PHARMACIA & UPJOHN COMPANY (US) 2000-03-28 US disclosed
US-5981537-A USEFUL IN THE TREATMENT OF INDIVIDUALS WHO ARE HIV POSITIVE PHARMACIA & UPJOHN COMPANY (US) 1999-11-09 US disclosed
WO-1999019304-A9 ALPHA-ALKYLTHIO SUBSTITUTED PYRIMIDINE ETHERS AND THIOETHERS AS VIRAL REVERSE TRANSCRIPTASE INHIBITORS UPJOHN CO (US) 1999-07-08 WO disclosed
WO-1999019304-A2 ALPHA-ALKYLTHIO SUBSTITUTED PYRIMIDINE ETHERS AND THIOETHERS AS VIRAL REVERSE TRANSCRIPTASE INHIBITORS PHARMACIA & UPJOHN COMPANY (US) 1999-04-22 WO disclosed
EP-0824524-A1 ALPHA-SUBSTITUTED PYRIMIDINE-THIOALKYL AND ALKYLETHER COMPOUNDS AS INHIBITORS OF VIRAL REVERSE TRANSCRIPTASE PHARMACIA & UPJOHN COMPANY (US) 1998-02-25 EP disclosed
WO-1996035678-A1 ALPHA-SUBSTITUTED PYRIMIDINE-THIOALKYL AND ALKYLETHER COMPOUNDS AS INHIBITORS OF VIRAL REVERSE TRANSCRIPTASE PHARMACIA & UPJOHN COMPANY (US) 1996-11-14 WO disclosed
EP-0728130-A1 PYRIMIDINE-THIOALKYL AND ALKYLETHER COMPOUNDS PHARMACIA & UPJOHN COMPANY (US) 1996-08-28 EP disclosed
WO-1995013267-A1 PYRIMIDINE-THIOALKYL AND ALKYLETHER COMPOUNDS THE UPJOHN COMPANY (US) 1995-05-18 WO disclosed