SCHEMBL6637653

SCHEMBL6637653

Cc1c(NC(=O)OC(C)(C)C)ccc2nc(N(CCc3ccccc3)C(=O)N(C)CCc3ccncc3)oc(=O)c12

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTRB1 P17538 2/20 0.51
ELANE P08246 2/20 0.51
CTSK P43235 2/20 0.36
P2RX7 Q99572 1/20 0.34
CYP17A1 P05093 2/20 0.34
TAAR1 Q96RJ0 1/20 0.33
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
BRD4 O60885 1/20 0.32
NPY5R Q15761 1/20 0.31
BUB1 O43683 1/20 0.31
LIPE Q05469 1/20 0.30
PPARG P37231 1/20 0.30
PPARD Q03181 1/20 0.30
PPARA Q07869 1/20 0.30
ABCC1 P33527 1/20 0.30
TOP2A P11388 1/20 0.30
TOP2B Q02880 1/20 0.30
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6637590 0.96 CTRB1 (0.49) CTRB1ELANECTSKP2RX7CYP17A1
SCHEMBL6639583 0.93 CTRB1 (0.49) CTRB1ELANECTSKP2RX7TAAR1
SCHEMBL6636633 0.92 CTRB1 (0.46) CTRB1ELANECTSKP2RX7CYP17A1
SCHEMBL6638443 0.90 CTRB1 (0.47) CTRB1ELANECTSKP2RX7MAPT
SCHEMBL6722616 0.88 CTRB1 (0.48) CTRB1ELANECTSKP2RX7TAAR1
SCHEMBL6634617 0.87 CTRB1 (0.47) CTRB1ELANECTSKP2RX7NPC1
SCHEMBL6636916 0.87 CTRB1 (0.50) CTRB1ELANECTSKP2RX7CYP17A1
SCHEMBL6636983 0.87 CTRB1 (0.46) CTRB1ELANECTSKP2RX7
SCHEMBL6637258 0.85 CTRB1 (0.51) CTRB1ELANECTSKP2RX7CYP17A1
SCHEMBL6637260 0.85 CTRB1 (0.46) CTRB1ELANECYP17A1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040116420-A1 Remedial agent for viral infectious disease ASAHI KASEI PHARMA CORPORATION (JP) 2004-06-17 US disclosed
EP-1403269-A1 REMEDIAL AGENT FOR VIRAL INFECTIOUS DISEASE Asahi Kasei Pharma Corporation (JP) 2004-03-31 EP disclosed