Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.49 |
| ▸ | PKLR | P30613 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6633880 | 0.87 | F2 (0.49) | F2PKLRKMT2AMEN1GLO1 | |
| Hydrochloric Acid SCHEMBL6638514 | 0.85 | F2 (0.67) | F2PKLRKMT2AMEN1ALDH1A1 | |
| SCHEMBL6633872 | 0.82 | F2 (0.50) | F2PKLRKMT2AMEN1TP53 | |
| SCHEMBL8026354 | 0.80 | F2 (0.74) | F2PKLRKMT2AMEN1TP53 | |
| SCHEMBL8026334 | 0.77 | F2 (0.55) | F2PKLRKMT2AMEN1TP53 | |
| SCHEMBL6634709 | 0.76 | F2 (0.57) | F2PKLRKMT2AMEN1GLO1 | |
| SCHEMBL6636395 | 0.75 | F2 (0.58) | F2PKLRKMT2AMEN1GLO1 | |
| SCHEMBL6634125 | 0.75 | F2 (0.58) | F2PKLRKMT2AMEN1GLO1 | |
| SCHEMBL7985209 | 0.75 | F2 (0.60) | F2PKLRKMT2AMEN1TP53 | |
| SCHEMBL8029757 | 0.74 | F2 (0.55) | F2PKLRKMT2AMEN1GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100795-B1 | DISUBSTITUTED BICYCLIC HETEROCYCLES HAVING, IN PARTICULAR, A THROMBIN INHIBITIVE EFFECT | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-06-09 | — | — | EP | disclosed |
| US-6121308-A | INDOLE AND BENZIMIDAZOLE ANTITHROMBOTIC COMPOUNDS, SUCH AS 1-METHYL-2-(N-(4-AMIDINOPHENYL)-AMINOMETHYL)-5-(N-(HYDROXYCARBONYLMETHYL) -QUINOLINE-8-SULPHONYLAMINO)-INDOLE | BOEHRINGER INGELHEIM KG (DE) | 2000-09-19 | — | — | US | disclosed |