Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 15/20 | 0.54 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6641590 | 1.00 | HTR1A (0.54) | HTR1ACDK8RORC | |
| SCHEMBL6636682 | 0.92 | HTR1A (0.56) | HTR1ARORC | |
| SCHEMBL6637402 | 0.92 | HTR1A (0.56) | HTR1ARORC | |
| SCHEMBL6636686 | 0.92 | HTR1A (0.56) | HTR1ARORC | |
| SCHEMBL6641623 | 0.90 | HTR1A (0.54) | HTR1ARORC | |
| SCHEMBL6641620 | 0.90 | HTR1A (0.54) | HTR1ARORC | |
| SCHEMBL6639740 | 0.86 | HTR1A (0.60) | HTR1A | |
| SCHEMBL6636310 | 0.86 | HTR1A (0.58) | HTR1A | |
| SCHEMBL6640972 | 0.86 | HTR1A (0.58) | HTR1A | |
| SCHEMBL6636312 | 0.86 | HTR1A (0.58) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147083-B1 | ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | WYETH CORP (US) | 2004-06-16 | — | — | EP | disclosed |
| US-6465482-B2 | ANTIDEPRESSANTS; ANXIOLYTIC AGENTS; SEROTONIN-AFFECTED NERVOUS SYSTEM DISORDERS; ACTING AT THE 5-HT1A AUTORECEPTORS CONCOMMITANTLY WITH 5-HT TRANSPORTERS; ANTISEROTONIN AGENTS; SEROTONIN REUPTAKE INHIBITORS; HT3 RECEPTOR ANTAGONISTS | WYETH | 2002-10-15 | — | — | US | disclosed |
| US-6313126-B1 | FOR THRERAPY OF DISORDERS ASSOCIATED WITH DYSFUNCTION IN SEROTONERGIC NEUROTRANSMISSION, INCLUDING DEPRESSION AND ANXIETY | AMERICAN HOME PRODUCTS CORP | 2001-11-06 | — | — | US | disclosed |