Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 18/20 | 1.00 |
| ▸ | HDAC2 | Q92769 | 17/20 | 1.00 |
| ▸ | HDAC1 | Q13547 | 16/20 | 1.00 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.65 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.65 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6637069 | 0.94 | HDAC3 (0.89) | HDAC3HDAC2HDAC1HDAC8NCOR2 | |
| SCHEMBL17141739 | 0.91 | HDAC3 (1.00) | HDAC3HDAC2HDAC1HDAC8NCOR2 | |
| SCHEMBL6358652 | 0.85 | HDAC3 (0.74) | HDAC3HDAC2HDAC1HDAC8HDAC6 | |
| SCHEMBL6638062 | 0.84 | HDAC3 (0.77) | HDAC3HDAC2HDAC1HDAC6 | |
| SCHEMBL6636519 | 0.81 | HDAC3 (0.82) | HDAC3HDAC2HDAC1HDAC8NCOR2 | |
| SCHEMBL28918328 | 0.80 | HDAC3 (1.00) | HDAC3HDAC2HDAC1HDAC8NCOR2 | |
| SCHEMBL3247728 | 0.79 | HDAC1 (0.74) | HDAC3HDAC2HDAC1HDAC8HDAC6 | |
| SCHEMBL28444240 | 0.79 | HDAC1 (0.74) | HDAC3HDAC2HDAC1HDAC8HDAC6 | |
| SCHEMBL11220445 | 0.79 | HDAC1 (0.74) | HDAC3HDAC2HDAC1HDAC8HDAC6 | |
| SCHEMBL9099931 | 0.79 | HDAC1 (0.74) | HDAC3HDAC2HDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190308932-A1 | HISTONE DEACETYLASE INHIBITORS AND USES THEREOF | MEDICAL UNIVERSITY OF SOUTH CAROLINA | 2019-10-10 | — | — | US | claimed |
| WO-2018071740-A1 | HISTONE DEACETYLASE INHIBITORS AND USES THEREOF | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2018-04-19 | — | — | WO | claimed |
| US-20170174619-A1 | HDAC INHIBITOR COMPOUNDS AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. | 2017-06-22 | — | — | US | claimed |
| WO-2015153516-A1 | HDAC INHIBITOR COMPOUNDS AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) | 2015-10-08 | — | — | WO | claimed |
| US-11731934-B2 | HDAC inhibitor compounds and methods of treatment | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2023-08-22 | — | — | US | disclosed |
| US-11731934-B2 | HDAC inhibitor compounds and methods of treatment | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2023-08-22 | — | — | US | disclosed |
| US-20210009509-A1 | HDAC INHIBITOR COMPOUNDS AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. | 2021-01-14 | — | — | US | disclosed |
| US-20210009509-A1 | HDAC INHIBITOR COMPOUNDS AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. | 2021-01-14 | — | — | US | disclosed |
| US-10870618-B2 | Histone deacetylase inhibitors and uses thereof | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2020-12-22 | — | — | US | disclosed |
| US-10870618-B2 | Histone deacetylase inhibitors and uses thereof | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2020-12-22 | — | — | US | disclosed |
| US-10807944-B2 | HDAC inhibitor compounds and methods of treatment | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2020-10-20 | — | — | US | disclosed |
| US-10807944-B2 | HDAC inhibitor compounds and methods of treatment | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2020-10-20 | — | — | US | disclosed |
| WO-2018071740-A1 | HISTONE DEACETYLASE INHIBITORS AND USES THEREOF | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2018-04-19 | — | — | WO | disclosed |
| US-20170174619-A1 | HDAC INHIBITOR COMPOUNDS AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. | 2017-06-22 | — | — | US | disclosed |
| US-20170174619-A1 | HDAC INHIBITOR COMPOUNDS AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. | 2017-06-22 | — | — | US | disclosed |
| WO-2015153516-A1 | HDAC INHIBITOR COMPOUNDS AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) | 2015-10-08 | — | — | WO | disclosed |
| WO-2015153516-A1 | HDAC INHIBITOR COMPOUNDS AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) | 2015-10-08 | — | — | WO | disclosed |
| EP-1420044-A2 | Rubber composition and pneumatic tire | Bridgestone Corporation (JP) | 2004-05-19 | — | — | EP | disclosed |
| US-6380288-B1 | LOW HEAT GENERATION PROPERTY, AGING REISTANCE, ALSO FOR PRODUCING VIBRATION ISOLATORS, BELTS AND HOSES AS WELL AS TIRE MATERIALS SUCH AS TIRE TREADS, UNDERTREADS, CARCASSES, SIDE WALLS AND BEADS | BRIDGESTONE CORPORATION | 2002-04-30 | — | — | US | disclosed |
| EP-0909788-A1 | RUBBER COMPOSITION AND PNEUMATIC TIRES | Bridgestone Corporation (JP) | 1999-04-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10870618-B2 | Histone deacetylase inhibitors and uses thereof | HDAC1, HDAC5, HDAC3 | HDAC3 3/4885HDAC2 7/4885HDAC1 1/4885 |
| US-20170174619-A1 | HDAC INHIBITOR COMPOUNDS AND METHODS OF TREATMENT | HDAC4, HDAC1, HDAC5 | HDAC3 4/4885HDAC2 5/4885HDAC1 2/4885 |
| US-20190308932-A1 | HISTONE DEACETYLASE INHIBITORS AND USES THEREOF | HDAC1, HDAC5, HDAC3 | HDAC3 3/4885HDAC2 7/4885HDAC1 1/4885 |
| US-11731934-B2 | HDAC inhibitor compounds and methods of treatment | HDAC4, HDAC1, HDAC5 | HDAC3 4/4885HDAC2 5/4885HDAC1 2/4885 |
| US-20210009509-A1 | HDAC INHIBITOR COMPOUNDS AND METHODS OF TREATMENT | HDAC4, HDAC1, HDAC5 | HDAC3 4/4885HDAC2 5/4885HDAC1 2/4885 |
| US-10807944-B2 | HDAC inhibitor compounds and methods of treatment | HDAC4, HDAC1, HDAC5 | HDAC3 4/4885HDAC2 5/4885HDAC1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.