Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | F9 | P00740 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | F11 | P03951 | 1/20 | 0.39 |
| ▸ | F7 | P08709 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6638639 | 0.91 | CHEK1 (0.42) | PDE10AJAK2CDK4CCNA2JAK1 | |
| SCHEMBL5952544 | 0.87 | FGFR1 (0.46) | PIM1PIM3AURKBPDE10AJAK2 | |
| SCHEMBL4916396 | 0.84 | PDE10A (0.53) | PDE10AJAK2CDK4CCNA2JAK1 | |
| SCHEMBL5952146 | 0.84 | PDE10A (0.53) | PDE10AJAK2CDK4CCNA2JAK1 | |
| SCHEMBL6639186 | 0.82 | PDE10A (0.37) | AURKBPDE10AJAK2CDK2TYK2 | |
| SCHEMBL5953158 | 0.81 | PDE10A (0.51) | PDE10AJAK2CDK4CCNA2JAK1 | |
| SCHEMBL5953027 | 0.81 | CDK4 (0.61) | AURKBPDE10AJAK2CDK4CCNA2 | |
| SCHEMBL5952578 | 0.81 | MEN1 (0.51) | PDE10AJAK2CDK4CCNA2JAK1 | |
| SCHEMBL5952514 | 0.81 | PTGES (0.52) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL5952084 | 0.80 | CBFB (0.46) | PDE10AJAK2CDK4CCNA2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441725-A1 | BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS | Aventis Pharmaceuticals Inc. (US) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003035065-A1 | BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS | AVENTIS PHARMACEUTICALS INC (US) | 2003-05-01 | — | — | WO | disclosed |