SCHEMBL6640337

SCHEMBL6640337

O=C1CNc2ccc(CN[C@H]3CC[C@H](C(=O)O)CC3)nc2O1

nearest known ligand 0.36

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 3/20 0.36
HDAC1 Q13547 4/20 0.34
HDAC8 Q9BY41 4/20 0.34
HDAC6 Q9UBN7 4/20 0.34
PAICS P22234 2/20 0.33
KCNH2 Q12809 1/20 0.33
ALDH1A1 P00352 1/20 0.31
GAA P10253 1/20 0.31
PDE7A Q13946 1/20 0.31
SYK P43405 1/20 0.31
S1PR5 Q9H228 1/20 0.31
BTK Q06187 1/20 0.31
CYP4F2 P78329 1/20 0.30
CYP4A11 Q02928 1/20 0.30
IDH1 O75874 2/20 0.30
HDAC5 Q9UQL6 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5264542 0.74 LTA4H (0.43) LTA4HKCNH2ALDH1A1GAASYK
SCHEMBL5264546 0.74 LTA4H (0.43) LTA4HKCNH2ALDH1A1GAASYK
SCHEMBL14358515 0.70 SMN1; SMN2 (0.33)
SCHEMBL5262012 0.70 KCNH2 (0.54) KCNH2
SCHEMBL5262019 0.70 KCNH2 (0.54) KCNH2
SCHEMBL5260947 0.67 KMT2A (0.43) LTA4HHDAC8ALDH1A1GAA
SCHEMBL5260938 0.67 KMT2A (0.43) LTA4HHDAC8ALDH1A1GAA
SCHEMBL3578810 0.65 KCNH2 (0.54) KCNH2
SCHEMBL5260537 0.65 KCNH2 (0.54) KCNH2
SCHEMBL2370628 0.63 LTA4H (0.61) LTA4HALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1399443-A1 NITROGEN-CONTAINING BICYCLIC HETEROCYCLES FOR USE AS ANTIBACTERIALS SMITHKLINE BEECHAM PLC (GB) 2004-03-24 EP claimed
WO-2003087098-A1 NITROGEN-CONTAINING BICYCLIC HETEROCYCLES FOR USE AS ANTIBACTERIALS SMITHKLINE BEECHAM P.L.C. (GB) 2003-10-23 WO claimed
EP-1399443-A1 NITROGEN-CONTAINING BICYCLIC HETEROCYCLES FOR USE AS ANTIBACTERIALS SMITHKLINE BEECHAM PLC (GB) 2004-03-24 EP disclosed
WO-2003087098-A1 NITROGEN-CONTAINING BICYCLIC HETEROCYCLES FOR USE AS ANTIBACTERIALS SMITHKLINE BEECHAM P.L.C. (GB) 2003-10-23 WO disclosed