Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PNMT | P11086 | 8/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6640477 | 1.00 | MEN1 (0.51) | MEN1KMT2APNMTADRA2AADRA2B | |
| SCHEMBL6618053 | 0.86 | MEN1 (0.68) | MEN1KMT2APNMTADRA2AADRA2B | |
| SCHEMBL6616133 | 0.86 | MEN1 (0.68) | MEN1KMT2APNMTADRA2AADRA2B | |
| SCHEMBL6617718 | 0.84 | MEN1 (0.55) | MEN1KMT2AIDO1GSK3BCYP11B1 | |
| SCHEMBL6633380 | 0.83 | MEN1 (0.56) | MEN1KMT2APNMTADRA2AADRA2B | |
| SCHEMBL6615168 | 0.83 | MEN1 (0.56) | MEN1KMT2APNMTADRA2AADRA2B | |
| SCHEMBL6635942 | 0.83 | MEN1 (0.48) | MEN1KMT2APNMTCYP19A1CYP11B1 | |
| SCHEMBL6635946 | 0.83 | MEN1 (0.48) | MEN1KMT2APNMTCYP19A1CYP11B1 | |
| SCHEMBL6614938 | 0.81 | MEN1 (0.51) | MEN1KMT2APNMTADRA2AADRA2B | |
| SCHEMBL6614678 | 0.79 | MEN1 (0.58) | MEN1KMT2ACYP19A1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1481975-A1 | Inhibitors of farnesyl protein transferase | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-12-01 | — | — | EP | disclosed |
| US-6011029-A | BENZODIAZEPINE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-01-04 | — | — | US | disclosed |