Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | VCP | P55072 | 1/20 | 0.42 |
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.41 |
| ▸ | AGPAT2 | O15120 | 2/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6640744 | 0.88 | HRH4 (0.45) | AGPAT2HRH4ADORA2AADORA1SMN1; SMN2 | |
| SCHEMBL6641552 | 0.82 | EGFR (0.46) | EGFRVCPAGPAT2HRH4ADORA3 | |
| SCHEMBL6643416 | 0.82 | HRH4 (0.46) | AGPAT2HRH4SMN1; SMN2MEN1MAPT | |
| SCHEMBL6640850 | 0.79 | CYP2C19 (0.47) | AGPAT2HRH4SMN1; SMN2MAP4K4MEN1 | |
| SCHEMBL7114489 | 0.77 | AGPAT2 (0.49) | AGPAT2SMN1; SMN2MEN1MAPTKMT2A | |
| SCHEMBL6640911 | 0.76 | HRH4 (0.48) | EGFRVCPHRH4ADORA2AADORA1 | |
| SCHEMBL6640292 | 0.76 | EGFR (0.47) | EGFRVCPPFKFB3ADORA3ADORA2A | |
| SCHEMBL7114446 | 0.76 | PIK3CA (0.44) | AGPAT2HRH4ADORA2AADORA1SMN1; SMN2 | |
| SCHEMBL7112022 | 0.76 | HRH4 (0.42) | AGPAT2HRH4SMN1; SMN2MEN1MAPT | |
| SCHEMBL6640313 | 0.75 | SMN1; SMN2 (0.50) | ADORA3ADORA2AADORA2BADORA1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412327-A2 | INHIBITORS OF PROTEIN KINASE FOR THE TREATMENT OF DISEASE | LG Biomedical Institute (US) | 2004-04-28 | — | — | EP | claimed |
| WO-2002096867-A2 | INHIBITORS OF PROTEIN KINASE FOR THE TREATMENT OF DISEASE | LG BIOMEDICAL INSTITUTE (US) | 2002-12-05 | — | — | WO | claimed |
| US-20030208067-A1 | Inhibitors of protein kinase for the treatment of disease | LG BIOMEDICAL INSTITUTE | 2003-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030208067-A1 | Inhibitors of protein kinase for the treatment of disease | MAP3K20, MAP3K1, MAP3K2 | EGFR 872/4885VCP 1531/4885PFKFB3 744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.