Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | PDE5A | O76074 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6648050 | 0.96 | KMT2A (0.45) | KMT2AMEN1PDE5APOLBLMNA | |
| SCHEMBL6644709 | 0.94 | KMT2A (0.44) | KMT2AMEN1PDE5APOLBLMNA | |
| SCHEMBL6646060 | 0.94 | KMT2A (0.43) | KMT2AMEN1PDE5APKMPABPC1 | |
| SCHEMBL6644230 | 0.92 | KMT2A (0.53) | KMT2AMEN1PDE5APOLBPKM | |
| SCHEMBL6642309 | 0.92 | KMT2A (0.45) | KMT2AMEN1PDE5APOLBLMNA | |
| SCHEMBL6643697 | 0.92 | KMT2A (0.43) | KMT2AMEN1POLBLMNATSHR | |
| SCHEMBL6641750 | 0.91 | KMT2A (0.46) | KMT2AMEN1PDE5APOLBLMNA | |
| SCHEMBL6641264 | 0.90 | PDE5A (0.43) | KMT2AMEN1PDE5APOLBPKM | |
| SCHEMBL6642399 | 0.89 | PDE5A (0.48) | KMT2AMEN1PDE5APOLBLMNA | |
| SCHEMBL6475154 | 0.88 | KMT2A (0.46) | KMT2AMEN1PDE5APOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1257553-B1 | PYRROLOPYRIMIDINONE DERIVATIVES, PROCESS OF PREPARATION AND USE | SK CHEMICALS CO LTD (KR) | 2004-05-26 | — | — | EP | disclosed |