Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 7/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6645297 | 0.82 | HTR2A (0.45) | HTR2CHTR2AGAAMAPK1ALDH1A1 | |
| SCHEMBL6641924 | 0.80 | GAA (0.34) | HTR2CGAAMAPK1HTR6ALDH1A1 | |
| SCHEMBL6639026 | 0.79 | HTR2C (0.45) | HTR2CHTR2AGAAMAPK1ALDH1A1 | |
| SCHEMBL6641493 | 0.79 | HTR2A (0.45) | HTR2CHTR2AGAAMAPK1HTR6 | |
| SCHEMBL4048331 | 0.78 | HTR6 (0.52) | HTR2CHTR2AGAAMAPK1HTR6 | |
| SCHEMBL1092484 | 0.75 | HTR2A (0.68) | HTR2CHTR2AALDH1A1MAPTHPGD | |
| SCHEMBL6642682 | 0.75 | HTR6 (0.57) | HTR2CHTR2AGAAMAPK1HTR6 | |
| SCHEMBL905707 | 0.74 | HTR2C (0.38) | HTR2CHTR2AGAAMAPK1PTGS2 | |
| SCHEMBL6641185 | 0.74 | HTR2C (0.38) | HTR2CHTR2AGAAMAPK1PTGS2 | |
| SCHEMBL6642384 | 0.74 | HTR6 (0.56) | HTR2CHTR2AGAAHTR6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109813-B1 | PYRROLOINDOLES, PYRIDOINDOLES AND AZEPINOINDOLES AS 5-HT2C AGONISTS | VERNALIS RES LTD (GB) | 2004-08-11 | — | — | EP | disclosed |
| US-6433175-B1 | ANTISEROTONINE AGENTS | VERNALIS RESEARCH LIMITED (GB) | 2002-08-13 | — | — | US | disclosed |
| EP-1109813-A1 | PYRROLOINDOLES, PYRIDOINDOLES AND AZEPINOINDOLES AS 5-HT2C AGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000012510-A1 | PYRROLOINDOLES, PYRIDOINDOLES AND AZEPINOINDOLES AS 5-HT2C AGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |