Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 20/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | THRB | P10828 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3918418 | 0.92 | CHEK2 (0.84) | CHEK2MEN1THRBKMT2A | |
| SCHEMBL2318980 | 0.89 | CHEK2 (1.00) | CHEK2 | |
| SCHEMBL5634535 | 0.85 | CHEK2 (0.76) | CHEK2KMT2A | |
| SCHEMBL3925984 | 0.85 | CHEK2 (0.74) | CHEK2KMT2A | |
| SCHEMBL3178023 | 0.84 | CHEK2 (0.83) | CHEK2 | |
| SCHEMBL6641749 | 0.84 | CHEK2 (1.00) | CHEK2MEN1THRBKMT2A | |
| SCHEMBL3922206 | 0.83 | CHEK2 (1.00) | CHEK2MEN1THRBKMT2A | |
| SCHEMBL6641160 | 0.83 | CHEK2 (1.00) | CHEK2MEN1THRBKMT2A | |
| SCHEMBL6640139 | 0.83 | CHEK2 (1.00) | CHEK2MEN1THRBKMT2A | |
| SCHEMBL5252669 | 0.82 | CHEK2 (0.70) | CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1435947-A1 | 2-PHENYL BENZIMIDAZOLES AND IMIDAZO-[4,5]-PYRIDINES AS CDS1/CHK2-INHIBITORS AND ADJUVANTS TO CHEMOTHERAPY OR RADIATION THERAPY IN THE TREATMENT OF CANCER | Ortho-McNeil Pharmaceutical, Inc. (US) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003032984-A1 | 2-PHENYL BENZIMIDAZOLES AND IMIDAZO-[4,5]-PYRIDINES AS CDSI/CHK2-INHIBITORS AND ADJUVANTS TO CHEMOTHERAPY OR RADIATION THERAPY IN THE TREATMENT OF CANCER | ORTHO-MCNEIL PHARMACEUTICAL,INC. (US) | 2003-04-24 | — | — | WO | disclosed |