Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 7/20 | 0.63 |
| ▸ | SYK | P43405 | 4/20 | 0.62 |
| ▸ | GSK3B | P49841 | 2/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.54 |
| ▸ | AURKA | O14965 | 6/20 | 0.52 |
| ▸ | CDK1 | P06493 | 2/20 | 0.52 |
| ▸ | CDK2 | P24941 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 1/20 | 0.52 |
| ▸ | FES | P07332 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3270075 | 0.82 | IGF1R (0.82) | IGF1RSYKGSK3BMAPK8AURKA | |
| SCHEMBL3275303 | 0.81 | SYK (0.92) | IGF1RSYKGSK3BMAPK8AURKA | |
| SCHEMBL4459525 | 0.79 | IGF1R (1.00) | IGF1RSYKGSK3BMAPK8AURKA | |
| SCHEMBL655851 | 0.78 | AURKA (0.61) | IGF1RSYKGSK3BMAPK8AURKA | |
| SCHEMBL6829175 | 0.77 | SYK (0.83) | IGF1RSYKGSK3BMAPK8AURKA | |
| SCHEMBL656905 | 0.77 | SYK (1.00) | IGF1RSYKGSK3BMAPK8CDK1 | |
| SCHEMBL6642447 | 0.76 | IGF1R (0.50) | IGF1RSYKGSK3BMAPK8AURKA | |
| SCHEMBL7169368 | 0.76 | CYP3A4 (0.52) | — | |
| SCHEMBL6826392 | 0.76 | AURKA (0.67) | IGF1RSYKGSK3BAURKACDK1 | |
| SCHEMBL5261726 | 0.72 | IGF1R (0.85) | IGF1RSYKGSK3BMAPK8AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140860-B1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2004-09-22 | — | — | EP | disclosed |
| US-6593326-B1 | Useful as anti-cancer agents; and processes for their manufacture and pharmaceutical compositions containing them are described. Apoptotic effect in a warm-blooded animal such as man. | ASTRAZENECA AB (SE) | 2003-07-15 | — | — | US | disclosed |
| EP-1140860-A1 | PYRIMIDINE COMPOUNDS | AstraZeneca AB (SE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039101-A1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-07-06 | — | — | WO | disclosed |