Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 9/20 | 0.39 |
| ▸ | HTR2A | P28223 | 9/20 | 0.39 |
| ▸ | DRD3 | P35462 | 9/20 | 0.39 |
| ▸ | RBP4 | P02753 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.36 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7600035 | 0.83 | CHRM4 (0.50) | MAPT | |
| SCHEMBL6642596 | 0.76 | HTT (0.49) | DRD2HTR2ADRD3SMN1; SMN2 | |
| SCHEMBL5236782 | 0.76 | HTR2C (0.62) | HTR2CDRD2HTR2ADRD3NAMPT | |
| SCHEMBL6276568 | 0.76 | NPC1 (0.46) | DRD2DRD3PDE10AMAPK7NPC1 | |
| SCHEMBL6638468 | 0.75 | HTR2C (0.52) | HTR2CDRD2HTR2ADRD3NPC1 | |
| SCHEMBL4562941 | 0.73 | DRD4 (0.46) | RBP4NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL9571941 | 0.70 | HTR1A (0.44) | HTR2CDRD2HTR2A | |
| SCHEMBL1303713 | 0.70 | PDE10A (0.39) | PDE10ANPC1RAB9A | |
| SCHEMBL9984684 | 0.70 | PDE10A (0.39) | PDE10A | |
| SCHEMBL9988573 | 0.70 | PDE10A (0.43) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1078928-B1 | Pyridine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2004-05-12 | — | — | EP | disclosed |
| EP-1078928-A1 | Pyridine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2001-02-28 | — | — | EP | disclosed |