Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 14/20 | 0.49 |
| ▸ | GAK | O14976 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6637307 | 0.90 | EGFR (0.51) | EGFRERBB2GAK | |
| SCHEMBL6685298 | 0.85 | EGFR (0.49) | EGFRERBB2GAK | |
| SCHEMBL6258057 | 0.81 | EGFR (0.51) | EGFRERBB2GAK | |
| SCHEMBL6641709 | 0.81 | EGFR (0.54) | EGFRERBB2GAK | |
| SCHEMBL7067445 | 0.80 | EGFR (0.53) | EGFRERBB2GAK | |
| SCHEMBL6484932 | 0.79 | EGFR (0.72) | EGFRERBB2GAK | |
| SCHEMBL2702580 | 0.79 | EGFR (0.64) | EGFRERBB2GAKMEN1KMT2A | |
| SCHEMBL6485217 | 0.79 | EGFR (0.69) | EGFRERBB2 | |
| Hydrochloric Acid SCHEMBL6254830 | 0.79 | EGFR (0.60) | EGFRERBB2GAK | |
| SCHEMBL6257107 | 0.78 | EGFR (0.54) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463507-A1 | THIENOPYRIMIDINE COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003053446-A1 | THIENOPYRIMIDINE COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-07-03 | — | — | WO | disclosed |