Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 11/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.49 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.45 |
| ▸ | DDX3X | O00571 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3636338 | 0.86 | ABCG2 (0.47) | KMT2AABCG2PDE5AABCC1ALDH1A1 | |
| SCHEMBL848595 | 0.81 | KMT2A (0.53) | KMT2AABCG2PDE5AABCC1ALDH1A1 | |
| SCHEMBL6642187 | 0.81 | AKR1C3 (0.57) | KMT2AABCG2PDE5AABCC1ALDH1A1 | |
| SCHEMBL9402427 | 0.80 | KMT2A (0.65) | KMT2AABCG2PDE5AALDH1A1SMN1; SMN2 | |
| SCHEMBL6645636 | 0.79 | ABCG2 (0.50) | KMT2AABCG2PDE5AABCC1ALDH1A1 | |
| SCHEMBL6643376 | 0.79 | AKR1C3 (0.52) | KMT2AABCG2ABCC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL27800307 | 0.78 | ABCG2 (0.49) | KMT2AABCG2PDE5AABCC1ALDH1A1 | |
| SCHEMBL27800308 | 0.75 | ABCG2 (0.47) | KMT2AABCG2PDE5AABCC1ALDH1A1 | |
| SCHEMBL6644795 | 0.74 | KMT2A (0.45) | KMT2AABCG2ABCC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL18280294 | 0.72 | SMN1; SMN2 (0.51) | KMT2AABCG2PDE5AABCC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1224624-C | 1, 8-naphthyridin-2 (1H) -one derivatives | GRELAN PHARMACEUTICAL CO (JP) | 2005-10-26 | — | — | CN | disclosed |
| EP-1236725-B1 | NOVEL 1,8-NAPHTHYRIDIN-2(1H)-ONE DERIVATIVES | GRELAN PHARMACEUTICAL CO (JP) | 2004-03-10 | — | — | EP | disclosed |
| US-6642250-B2 | As phosphodiesterase inhibitor for prophylaxis and therapy of bronchial asthma; pneumonic diseases, pulmonary emphysema, chronic obstructive pulmonary disease acute respiratory distress syndrome (ARDS), and other respiratory diseases | GRELAN PHARMACEUTICAL CO., LTD. (JP) | 2003-11-04 | — | — | US | disclosed |
| CN-1407984-A | Novel 1, 8-naphthyridin-2 (1H) -one derivatives | GRELAN PHARMACEUTICAL CO (JP) | 2003-04-02 | — | — | CN | disclosed |
| US-20030036651-A1 | Novel 1,8-naphthyridin-2(1h)-one derivatives | GRELAN PHARMACEUTICAL CO., LTD. (JP) | 2003-02-20 | — | — | US | disclosed |
| EP-1236725-A1 | NOVEL 1,8-NAPHTHYRIDIN-2(1H)-ONE DERIVATIVES | Grelan Pharmaceutical Co., Ltd. (JP) | 2002-09-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030036651-A1 | Novel 1,8-naphthyridin-2(1h)-one derivatives | PDE3B, PDE4A, PDE4B | KMT2A 1653/4885ABCG2 840/4885PDE5A 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.