Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.49 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | DDX3X | O00571 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27800308 | 0.84 | ABCG2 (0.47) | ABCG2ABCC1KMT2AMEN1MAPT | |
| SCHEMBL27800296 | 0.80 | MAPT (0.45) | KMT2AMEN1MAPTNPC1RAB9A | |
| SCHEMBL848595 | 0.80 | KMT2A (0.53) | ABCG2ABCC1KMT2AMEN1MAPT | |
| SCHEMBL6642187 | 0.80 | AKR1C3 (0.57) | ABCG2ABCC1KMT2AMEN1MAPT | |
| SCHEMBL6643376 | 0.78 | AKR1C3 (0.52) | ABCG2ABCC1KMT2AMEN1MAPT | |
| SCHEMBL3632094 | 0.78 | SMN1; SMN2 (0.41) | ABCG2ABCC1KMT2AMEN1MAPT | |
| SCHEMBL6644658 | 0.78 | KMT2A (0.51) | ABCG2ABCC1KMT2AMEN1MAPT | |
| SCHEMBL6645636 | 0.76 | ABCG2 (0.50) | ABCG2ABCC1KMT2AMEN1MAPT | |
| SCHEMBL3636338 | 0.74 | ABCG2 (0.47) | ABCG2ABCC1KMT2AMEN1MAPT | |
| SCHEMBL13384757 | 0.72 | KCNH3 (0.46) | ABCG2ABCC1KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101679270-A | Dihydroquinone and dihydronaphthyridine inhibitors of JNK | HOFFMANN LA ROCHE | 2010-03-24 | — | — | CN | disclosed |