Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | BDKRB2 | P30411 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | TLR2 | O60603 | 1/20 | 0.37 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | CALCA | P06881 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5122193 | 1.00 | LMNA (0.41) | LMNAMAPTL3MBTL1BDKRB2ALDH1A1 | |
| SCHEMBL5127802 | 0.93 | LMNA (0.43) | LMNAMAPTL3MBTL1ALDH1A1PTGER4 | |
| SCHEMBL5130380 | 0.91 | LMNA (0.40) | LMNAMAPTL3MBTL1BDKRB2ALDH1A1 | |
| SCHEMBL5114844 | 0.90 | PTGER4 (0.39) | LMNAALDH1A1PTGER4TLR2TLR1 | |
| SCHEMBL5123596 | 0.89 | LMNA (0.43) | LMNAMAPTL3MBTL1ALDH1A1PTGER4 | |
| SCHEMBL5117196 | 0.88 | LMNA (0.39) | LMNAMAPTL3MBTL1ALDH1A1PTGER4 | |
| SCHEMBL13999142 | 0.88 | TP53 (0.43) | LMNAMAPTL3MBTL1ALDH1A1RECQL | |
| SCHEMBL14013053 | 0.88 | LMNA (0.36) | LMNAMAPTL3MBTL1BDKRB2ALDH1A1 | |
| SCHEMBL5118228 | 0.87 | LMNA (0.42) | LMNAMAPTL3MBTL1ALDH1A1PTGER4 | |
| SCHEMBL5121491 | 0.87 | VHL (0.41) | LMNAALDH1A1PTGER4TLR2TLR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441734-A1 | DIHYDROXYPYRIMIDINE CARBOXAMIDE INHIBITORS OF HIV INTEGRASE | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2004-08-04 | — | — | EP | claimed |
| WO-2003035076-A1 | DIHYDROXYPYRIMIDINE CARBOXAMIDE INHIBITORS OF HIV INTEGRASE | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2003-05-01 | — | — | WO | claimed |
| EP-1441734-A1 | DIHYDROXYPYRIMIDINE CARBOXAMIDE INHIBITORS OF HIV INTEGRASE | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003035076-A1 | DIHYDROXYPYRIMIDINE CARBOXAMIDE INHIBITORS OF HIV INTEGRASE | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2003-05-01 | — | — | WO | disclosed |