Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | PDE5A | O76074 | 16/20 | 0.54 |
| ▸ | PDE2A | O00408 | 2/20 | 0.54 |
| ▸ | PDE9A | O76083 | 2/20 | 0.54 |
| ▸ | PDE4A | P27815 | 2/20 | 0.54 |
| ▸ | PDE6C | P51160 | 2/20 | 0.54 |
| ▸ | PDE1A | P54750 | 2/20 | 0.54 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.54 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.54 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.54 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.54 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.54 |
| ▸ | PDE6D | O43924 | 1/20 | 0.54 |
| ▸ | PDE8A | O60658 | 1/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | PDE6A | P16499 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6646921 | 0.94 | PDE5A (0.53) | KMT2AKDM4EPDE5A | |
| SCHEMBL6642885 | 0.90 | KMT2A (0.59) | KMT2AKDM4EPDE5APDE2APDE9A | |
| SCHEMBL6644911 | 0.90 | KMT2A (0.59) | KMT2AKDM4EPDE5APDE2APDE9A | |
| SCHEMBL6640023 | 0.89 | KMT2A (0.59) | KMT2AKDM4EPDE5APDE2APDE9A | |
| SCHEMBL6645339 | 0.87 | PDE5A (0.73) | PDE5APDE2APDE9APDE4APDE6C | |
| SCHEMBL6642951 | 0.85 | PDE5A (0.69) | KMT2AKDM4EPDE5APDE2APDE9A | |
| SCHEMBL6644733 | 0.84 | PDE5A (0.66) | KMT2AKDM4EPDE5APDE6CPDE1A | |
| SCHEMBL6646508 | 0.84 | PDE5A (0.54) | KMT2AKDM4EPDE5A | |
| SCHEMBL6646139 | 0.84 | PDE5A (0.54) | KMT2AKDM4EPDE5A | |
| SCHEMBL6643883 | 0.83 | PDE5A (0.65) | PDE5APDE2APDE9APDE4APDE6C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1257553-B1 | PYRROLOPYRIMIDINONE DERIVATIVES, PROCESS OF PREPARATION AND USE | SK CHEMICALS CO LTD (KR) | 2004-05-26 | — | — | EP | disclosed |