Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | CRHBP | P24387 | 2/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4454961 | 0.73 | KMT2A (0.54) | KMT2AMEN1MAPK1TSHRTP53 | |
| SCHEMBL5829479 | 0.72 | KMT2A (0.78) | KMT2AMEN1TSHRTP53LMNA | |
| SCHEMBL30958764 | 0.72 | TSHR (0.57) | KMT2AMEN1TSHRTP53LMNA | |
| SCHEMBL1134878 | 0.72 | TSHR (0.57) | KMT2AMEN1TSHRTP53LMNA | |
| SCHEMBL2800954 | 0.71 | KMT2A (0.61) | KMT2AMEN1CRHBPCRHR2MAPK1 | |
| SCHEMBL18601034 | 0.70 | KMT2A (0.60) | KMT2AMEN1CRHBPCRHR2MAPK1 | |
| SCHEMBL5261945 | 0.70 | TSHR (0.59) | KMT2AMEN1MAPK1TSHRTP53 | |
| SCHEMBL30866830 | 0.70 | TSHR (0.59) | KMT2AMEN1MAPK1TSHRTP53 | |
| SCHEMBL4869072 | 0.69 | CRHBP (0.62) | KMT2AMEN1CRHBPCRHR2MAPK1 | |
| SCHEMBL3622390 | 0.69 | KMT2A (0.63) | KMT2AMEN1CRHBPCRHR2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373259-A1 | PYRIDAZINONE ALDOSE REDUCTASE INHIBITORS | Pfizer Products Inc. (US) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002079198-A1 | PYRIDAZINONE ALDOSE REDUCTASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2002-10-10 | — | — | WO | disclosed |