SCHEMBL6645801

SCHEMBL6645801

CC(Cl)(Cl)Cc1cccc2ccccc12

nearest known ligand 0.50

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 3/20 0.50
CYP1A2 P05177 2/20 0.50
CYP2C19 P33261 2/20 0.50
CYP2C9 P11712 1/20 0.48
TDP1 Q9NUW8 1/20 0.44
NR1I2 O75469 1/20 0.44
LMNA P02545 1/20 0.44
ADRA2A P08913 1/20 0.44
ACHE P22303 1/20 0.44
SLC6A2 P23975 1/20 0.44
HTR2A P28223 1/20 0.44
SLC6A4 P31645 1/20 0.44
KCNH2 Q12809 1/20 0.44
SIGMAR1 Q99720 1/20 0.44
ACP3 P15309 1/20 0.43
SSTR4 P31391 1/20 0.43
CASR P41180 1/20 0.43
NQO2 P16083 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17224808 0.83 CYP1A2 (0.52) CYP2D6CYP1A2CYP2C19CYP2C9TDP1
SCHEMBL31675157 0.83 CYP2D6 (0.53) CYP2D6CYP1A2CYP2C19CYP2C9TDP1
SCHEMBL11586023 0.83 CYP2D6 (0.53) CYP2D6CYP1A2CYP2C19CYP2C9TDP1
SCHEMBL4814074 0.82 CYP2D6 (0.52) CYP2D6CYP1A2CYP2C19CYP2C9TDP1
SCHEMBL17488720 0.80 CYP2D6 (0.50) CYP2D6CYP1A2CYP2C19CYP2C9TDP1
SCHEMBL8851072 0.80 CYP2C19 (0.50) CYP2D6CYP1A2CYP2C19CYP2C9TDP1
SCHEMBL7907369 0.80 CYP2C19 (0.50) CYP2D6CYP1A2CYP2C19CYP2C9TDP1
SCHEMBL2754934 0.80 CYP2D6 (0.50) CYP2D6CYP1A2CYP2C19CYP2C9TDP1
SCHEMBL808870 0.80 TDP1 (0.53) CYP2D6CYP1A2CYP2C19CYP2C9TDP1
SCHEMBL6437231 0.80 CYP2C19 (0.50) CYP2D6CYP1A2CYP2C19CYP2C9TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1377577-A1 PYRROLE DERIVATES FOR TREATING CYTOKINE MEDIATED DISEASES Sankyo Company Limited (JP) 2004-01-07 EP disclosed
WO-2002057264-A1 PYRROLE DERIVATES FOR TREATING CYTOKINE MEDIATED DISEASES SANKYO COMPANY LIMITED (JP) 2002-07-25 WO disclosed