Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.85 |
| ▸ | KIT | P10721 | 1/20 | 0.85 |
| ▸ | FLT3 | P36888 | 1/20 | 0.85 |
| ▸ | EGFR | P00533 | 4/20 | 0.67 |
| ▸ | LCK | P06239 | 3/20 | 0.67 |
| ▸ | ITK | Q08881 | 2/20 | 0.67 |
| ▸ | LYN | P07948 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL5819970 | 0.98 | BTK (0.82) | BTKKITFLT3EGFRLCK | |
| SCHEMBL17951520 | 0.94 | BTK (0.92) | BTKKITFLT3EGFRLCK | |
| SCHEMBL6430186 | 0.93 | BTK (0.74) | BTKKITFLT3EGFRLCK | |
| SCHEMBL30615720 | 0.92 | BTK (0.84) | BTKKITFLT3EGFRLCK | |
| SCHEMBL5823164 | 0.92 | BTK (0.84) | BTKKITFLT3EGFRLCK | |
| SCHEMBL19638299 | 0.92 | BTK (1.00) | BTKKITFLT3EGFRLCK | |
| SCHEMBL17951497 | 0.92 | BTK (1.00) | BTKKITFLT3EGFRLCK | |
| SCHEMBL6438133 | 0.89 | BTK (0.73) | BTKKITFLT3EGFRLCK | |
| SCHEMBL6430256 | 0.89 | BTK (0.69) | BTKKITFLT3EGFRLCK | |
| SCHEMBL7136201 | 0.88 | BTK (0.68) | BTKKITFLT3EGFRLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212327-B8 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2004-02-25 | — | — | EP | disclosed |
| EP-1212327-A2 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001019829-A2 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 2001-03-22 | — | — | WO | disclosed |