Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.48 |
| ▸ | APP | P05067 | 3/20 | 0.46 |
| ▸ | HTR1D | P28221 | 5/20 | 0.44 |
| ▸ | HTR1B | P28222 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | HTR1F | P30939 | 4/20 | 0.43 |
| ▸ | HTR1A | P08908 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5365293 | 0.89 | HTR6 (0.56) | HTR6APPHTR1DHTR1BCYP1A2 | |
| SCHEMBL6650632 | 0.87 | HTR6 (0.61) | HTR6APPHTR1DHTR1BCYP1A2 | |
| SCHEMBL6647840 | 0.80 | HTR6 (0.47) | HTR6APPHTR1DHTR1BCYP1A2 | |
| SCHEMBL5375337 | 0.79 | HTR6 (0.61) | HTR6APPHTR1DHTR1BCYP1A2 | |
| SCHEMBL5363994 | 0.78 | HTR6 (0.55) | HTR6APPHTR1DHTR1BCYP1A2 | |
| SCHEMBL5374013 | 0.77 | APP (0.58) | APPHTR1DHTR1BCYP1A2CYP3A4 | |
| SCHEMBL5365362 | 0.76 | HTR6 (0.76) | HTR6APPHTR1DHTR1BCYP1A2 | |
| SCHEMBL7867370 | 0.74 | APP (0.65) | APPHTR1DHTR1BCYP1A2CYP3A4 | |
| SCHEMBL6646899 | 0.73 | HTR6 (0.47) | HTR6 | |
| SCHEMBL5374640 | 0.72 | HTR6 (0.55) | HTR6HTR1DHTR1BCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377580-A2 | BENZENESULFONIC ACID INDOL-5-YL ESTERS AS ANTAGONISTS OF THE 5-HT6 RECEPTOR | ELI LILLY AND COMPANY (US) | 2004-01-07 | — | — | EP | disclosed |
| WO-2002060871-A2 | BENZENESULFONIC ACID INDOL-5-YL ESTERS AS ANTAGONISTS OF THE 5-HT6 RECEPTOR | ELI LILLY AND COMPANY (US) | 2002-08-08 | — | — | WO | disclosed |