Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 20/20 | 0.80 |
| ▸ | CDK2 | P24941 | 17/20 | 0.80 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | LTK | P29376 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5581900 | 0.88 | CDK4 (1.00) | CDK4CDK2IGF1R | |
| SCHEMBL14632119 | 0.88 | CDK4 (1.00) | CDK4CDK2CCNE1DAPK3JAK2 | |
| SCHEMBL29644990 | 0.88 | CDK4 (1.00) | CDK4CDK2IGF1R | |
| SCHEMBL29644986 | 0.88 | CDK4 (1.00) | CDK4CDK2IGF1R | |
| SCHEMBL7239268 | 0.87 | CDK4 (0.78) | CDK4CDK2CDK1CCNE1 | |
| SCHEMBL7238706 | 0.86 | CDK4 (0.79) | CDK4CDK2CDK1CCNE1DAPK3 | |
| SCHEMBL6646426 | 0.84 | CDK4 (0.73) | CDK4CDK2 | |
| SCHEMBL6644644 | 0.84 | CDK4 (0.75) | CDK4CDK2CDK1CCNE1DAPK3 | |
| SCHEMBL6643501 | 0.83 | CDK4 (0.69) | CDK4CDK2CDK1CCNE1DAPK3 | |
| Hydrochloric Acid SCHEMBL7232203 | 0.83 | CDK4 (0.73) | CDK4CDK2CDK1CCNE1DAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140860-B1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2004-09-22 | — | — | EP | disclosed |
| US-6593326-B1 | Useful as anti-cancer agents; and processes for their manufacture and pharmaceutical compositions containing them are described. Apoptotic effect in a warm-blooded animal such as man. | ASTRAZENECA AB (SE) | 2003-07-15 | — | — | US | disclosed |
| EP-1140860-A1 | PYRIMIDINE COMPOUNDS | AstraZeneca AB (SE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039101-A1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-07-06 | — | — | WO | disclosed |