Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 20/20 | 0.78 |
| ▸ | CDK2 | P24941 | 17/20 | 0.78 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7236132 | 0.89 | CDK4 (0.72) | CDK4CDK2CDK1CCNE1 | |
| SCHEMBL6644644 | 0.89 | CDK4 (0.75) | CDK4CDK2CDK1CCNE1 | |
| Hydrochloric Acid SCHEMBL7232203 | 0.88 | CDK4 (0.73) | CDK4CDK2CDK1CCNE1 | |
| SCHEMBL7238750 | 0.88 | CDK4 (0.72) | CDK4CDK2CDK1CCNE1 | |
| SCHEMBL29644990 | 0.87 | CDK4 (1.00) | CDK4CDK2 | |
| SCHEMBL6645907 | 0.87 | CDK4 (0.80) | CDK4CDK2CDK1CCNE1 | |
| SCHEMBL29644986 | 0.87 | CDK4 (1.00) | CDK4CDK2 | |
| SCHEMBL5581900 | 0.87 | CDK4 (1.00) | CDK4CDK2 | |
| SCHEMBL14632119 | 0.87 | CDK4 (1.00) | CDK4CDK2CCNE1 | |
| SCHEMBL6643501 | 0.86 | CDK4 (0.69) | CDK4CDK2CDK1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6593326-B1 | Useful as anti-cancer agents; and processes for their manufacture and pharmaceutical compositions containing them are described. Apoptotic effect in a warm-blooded animal such as man. | ASTRAZENECA AB (SE) | 2003-07-15 | — | — | US | disclosed |