Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10163026 | 0.78 | GSK3B (0.44) | GSK3BALDH1A1MAOBPTGS1PTGS2 | |
| SCHEMBL17912769 | 0.77 | AOC3 (0.44) | AOC3 | |
| SCHEMBL4488325 | 0.76 | HTR2A (0.39) | PTGS1PTGS2CALM1 | |
| SCHEMBL1498780 | 0.75 | CALM1 (0.55) | ALDH1A1AOC3MAOBMAOACALM1 | |
| SCHEMBL3468774 | 0.75 | AOC3 (0.44) | AOC3CALM1 | |
| SCHEMBL31650021 | 0.75 | AOC3 (0.44) | AOC3CALM1 | |
| SCHEMBL1704793 | 0.74 | CALM1 (0.44) | HPGDCALM1 | |
| SCHEMBL11406170 | 0.74 | CALM1 (0.44) | ALDH1A1AOC3MAOBMAOACALM1 | |
| Bromide SCHEMBL5088657 | 0.73 | HTR2A (0.42) | HPGDCALM1 | |
| Hydrochloric Acid SCHEMBL5088464 | 0.73 | HTR2A (0.42) | MAOBMAOAHPGDCALM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1389210-A1 | TRICYCLIC DIHYDRO-QUINOLINE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Les Laboratoires Servier (FR) | 2004-02-18 | — | — | EP | disclosed |
| WO-2002094835-A1 | TRICYCLIC DIHYDRO-QUINOLINE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2002-11-28 | — | — | WO | disclosed |