Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 7/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6646351 | 0.88 | AKR1B1 (0.47) | AKR1B1MAPTSMN1; SMN2 | |
| SCHEMBL3687096 | 0.72 | AKR1B1 (0.56) | AKR1B1HTR6MCL1PKMRXFP1 | |
| SCHEMBL3684433 | 0.71 | MCL1 (0.56) | AKR1B1HTR6MCL1PKMRXFP1 | |
| SCHEMBL6646151 | 0.67 | AKR1B1 (0.60) | AKR1B1HTR6MCL1PKMRXFP1 | |
| SCHEMBL13484254 | 0.66 | AKR1B1 (0.65) | AKR1B1HTR6MCL1PKMRXFP1 | |
| SCHEMBL690925 | 0.66 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL30977156 | 0.66 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL27598387 | 0.65 | AKR1B1 (0.57) | AKR1B1HTR6MCL1PKMRXFP1 | |
| SCHEMBL13211795 | 0.64 | AKR1B1 (0.63) | AKR1B1HTR6MCL1PKMRXFP1 | |
| SCHEMBL4451859 | 0.64 | AKR1B1 (0.61) | AKR1B1HTR6MCL1PKMRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373259-A1 | PYRIDAZINONE ALDOSE REDUCTASE INHIBITORS | Pfizer Products Inc. (US) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002079198-A1 | PYRIDAZINONE ALDOSE REDUCTASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2002-10-10 | — | — | WO | disclosed |