Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 11/20 | 0.60 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6646356 | 0.88 | AKR1B1 (0.59) | AKR1B1KCNH2MEN1KMT2A | |
| SCHEMBL690925 | 0.75 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL30977156 | 0.75 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL3687096 | 0.72 | AKR1B1 (0.56) | AKR1B1MCL1HTR6KCNH2PKM | |
| SCHEMBL4450414 | 0.72 | AKR1B1 (0.54) | AKR1B1MCL1HTR6PKMRXFP1 | |
| SCHEMBL3684433 | 0.71 | MCL1 (0.56) | AKR1B1MCL1HTR6KCNH2PKM | |
| SCHEMBL13484254 | 0.71 | AKR1B1 (0.65) | AKR1B1MCL1HTR6KCNH2PKM | |
| SCHEMBL13211795 | 0.69 | AKR1B1 (0.63) | AKR1B1MCL1HTR6KCNH2PKM | |
| SCHEMBL4451859 | 0.68 | AKR1B1 (0.61) | AKR1B1MCL1HTR6KCNH2PKM | |
| SCHEMBL6646147 | 0.67 | AKR1B1 (0.49) | AKR1B1MCL1HTR6KCNH2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373259-A1 | PYRIDAZINONE ALDOSE REDUCTASE INHIBITORS | Pfizer Products Inc. (US) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002079198-A1 | PYRIDAZINONE ALDOSE REDUCTASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2002-10-10 | — | — | WO | disclosed |