Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.61 |
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.58 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
| ▸ | IDH1 | O75874 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6647164 | 0.91 | KDM4E (0.59) | KDM4ERAB9ALMNASMN1; SMN2CYP19A1 | |
| SCHEMBL6628863 | 0.88 | CYP19A1 (0.48) | KDM4ERAB9ALMNASMN1; SMN2CYP19A1 | |
| SCHEMBL6628865 | 0.87 | CYP19A1 (0.58) | KDM4ERAB9ALMNASMN1; SMN2CYP19A1 | |
| SCHEMBL6649987 | 0.87 | KDM4E (0.56) | KDM4ERAB9ACYP19A1SREBF2NPC1 | |
| SCHEMBL6652389 | 0.86 | KDM4E (0.59) | KDM4ERAB9ACYP19A1SREBF2NPC1 | |
| SCHEMBL6648675 | 0.86 | EIF4E (0.58) | KDM4ERAB9ANPC1MEN1KMT2A | |
| SCHEMBL6646768 | 0.85 | CYP19A1 (0.56) | RAB9ACYP19A1MAPTNPC1MEN1 | |
| SCHEMBL6649452 | 0.84 | SMN1; SMN2 (0.51) | KDM4ERAB9ALMNASMN1; SMN2CYP19A1 | |
| SCHEMBL6626251 | 0.84 | KDM4E (0.52) | KDM4ERAB9ALMNASMN1; SMN2CYP19A1 | |
| SCHEMBL6648866 | 0.83 | KDM4E (0.56) | KDM4ERAB9ALMNASMN1; SMN2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432706-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | Bayer Pharmaceuticals Corporation (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003027085-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |