Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | AR | P10275 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | CYP19A1 | P11511 | 10/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | AXL | P30530 | 1/20 | 0.54 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.54 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.54 |
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
| ▸ | C1S | P09871 | 1/20 | 0.50 |
| ▸ | SREBF2 | Q12772 | 2/20 | 0.49 |
| ▸ | HPGDS | O60760 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6649987 | 0.97 | KDM4E (0.56) | KDM4EARKMT2ACYP19A1RAB9A | |
| SCHEMBL6646344 | 0.90 | KDM4E (0.57) | KDM4EARKMT2ACYP19A1RAB9A | |
| SCHEMBL6650443 | 0.88 | SREBF2 (0.55) | KDM4EARKMT2ACYP19A1RAB9A | |
| SCHEMBL6628863 | 0.88 | CYP19A1 (0.48) | KDM4EARKMT2ACYP19A1RAB9A | |
| SCHEMBL6646406 | 0.86 | KDM4E (0.61) | KDM4EKMT2ACYP19A1RAB9AALDH1A1 | |
| SCHEMBL6628865 | 0.86 | CYP19A1 (0.58) | KDM4EKMT2ACYP19A1RAB9AALDH1A1 | |
| SCHEMBL6646510 | 0.86 | CDC25A (0.56) | KDM4EARKMT2ACYP19A1RAB9A | |
| SCHEMBL6646768 | 0.85 | CYP19A1 (0.56) | KMT2ACYP19A1RAB9AALDH1A1NPC1 | |
| SCHEMBL6651298 | 0.84 | CYP19A1 (0.47) | KDM4EARKMT2ACYP19A1RAB9A | |
| SCHEMBL6626251 | 0.83 | KDM4E (0.52) | KDM4EARKMT2ACYP19A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432706-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | Bayer Pharmaceuticals Corporation (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003027085-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |