Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4E | P06730 | 19/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6651612 | 0.82 | C1S (0.54) | EIF4E | |
| SCHEMBL6649219 | 0.80 | EIF4E (0.44) | EIF4ENPC1L3MBTL1 | |
| SCHEMBL6647859 | 0.80 | HSD17B10 (0.48) | NPC1 | |
| SCHEMBL6644836 | 0.76 | CYP19A1 (0.47) | NPC1L3MBTL1 | |
| SCHEMBL1206979 | 0.75 | EIF4E (0.65) | EIF4ENPC1 | |
| SCHEMBL6367549 | 0.72 | HDAC3 (0.49) | EIF4E | |
| SCHEMBL1208143 | 0.71 | EIF4E (0.70) | EIF4E | |
| SCHEMBL6648869 | 0.71 | EIF4E (0.55) | EIF4ENPC1 | |
| SCHEMBL3026474 | 0.70 | MGAM (0.55) | EIF4ENPC1L3MBTL1 | |
| SCHEMBL220611 | 0.70 | MGAM (0.55) | EIF4ENPC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432706-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | Bayer Pharmaceuticals Corporation (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003027085-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |