Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | ADK | P55263 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ME2 | P23368 | 1/20 | 0.32 |
| ▸ | ME1 | P48163 | 1/20 | 0.32 |
| ▸ | ME3 | Q16798 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5916508 | 0.86 | CYP3A4 (0.40) | MMP7KDM4ECYP3A4MMP13USP2 | |
| SCHEMBL5916509 | 0.86 | CYP3A4 (0.40) | MMP7KDM4ECYP3A4MMP13USP2 | |
| SCHEMBL6645919 | 0.84 | MMP7 (0.40) | MMP7KDM4ECYP3A4MMP13USP2 | |
| SCHEMBL5916458 | 0.84 | MMP7 (0.42) | MMP7KDM4EL3MBTL1CYP3A4MMP13 | |
| SCHEMBL5916453 | 0.84 | MMP7 (0.42) | MMP7KDM4EL3MBTL1CYP3A4MMP13 | |
| SCHEMBL5916456 | 0.84 | MMP7 (0.42) | MMP7KDM4EL3MBTL1CYP3A4MMP13 | |
| SCHEMBL5916526 | 0.80 | CYP3A4 (0.50) | MMP7KDM4EL3MBTL1CYP3A4MMP13 | |
| SCHEMBL5916529 | 0.80 | CYP3A4 (0.50) | MMP7KDM4EL3MBTL1CYP3A4MMP13 | |
| SCHEMBL5916557 | 0.80 | CYP3A4 (0.50) | MMP7KDM4EL3MBTL1CYP3A4MMP13 | |
| SCHEMBL5916421 | 0.79 | MMP7 (0.44) | MMP7KDM4EL3MBTL1CYP3A4MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1417201-A1 | ARYLPIPERAZINES AND ARYLPIPERIDINES AND THEIR USE AS METALLOPROTEINASE INHIBITING AGENTS | AstraZeneca AB (SE) | 2004-05-12 | — | — | EP | disclosed |
| WO-2003014111-A1 | ARYLPIPERAZINES AND ARYLPIPERIDINES AND THEIR USE AS METALLOPROTEINASE INHIBITING AGENTS | ASTRAZENECA AB (SE) | 2003-02-20 | — | — | WO | disclosed |