Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN7 | P35236 | 1/20 | 0.57 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.57 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | BCL9 | O00512 | 1/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6646865 | 0.85 | HTR2A (0.54) | PTPN7PTPN12PTPN22HTR2AMAPT | |
| SCHEMBL6652016 | 0.84 | HTR2A (0.55) | PTPN7PTPN12PTPN22HTR2AMAPT | |
| SCHEMBL7463242 | 0.84 | HTR2A (0.58) | PTPN7PTPN12PTPN22HTR2AMAPT | |
| SCHEMBL1197368 | 0.81 | HTR2A (0.50) | PTPN7PTPN12PTPN22HTR2AMAPT | |
| SCHEMBL1976715 | 0.81 | HTR2A (0.58) | PTPN7PTPN12PTPN22HTR2AMAPT | |
| SCHEMBL5827968 | 0.80 | HTR2A (0.80) | HTR2AMAPK1BCL9CTNNB1GAA | |
| SCHEMBL9144432 | 0.80 | HTR2A (0.70) | PTPN7PTPN12PTPN22HTR2AMAPT | |
| SCHEMBL29586964 | 0.79 | HTR2A (0.62) | PTPN7PTPN12PTPN22HTR2AMAPK1 | |
| SCHEMBL1714950 | 0.79 | HTR2A (0.70) | HTR2AMAPTTDP1BCL9CTNNB1 | |
| SCHEMBL15416492 | 0.78 | HTR2A (0.62) | PTPN7PTPN12PTPN22HTR2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1482940-A2 | PRODRUGS OF SUBSTITUTED POLYCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | Pharmacia Corporation (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003028729-A2 | PRODRUGS OF SUBSTITUTED POLYCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |