Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.48 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.48 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.48 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | RXRB | P28702 | 1/20 | 0.46 |
| ▸ | RXRG | P48443 | 1/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15416492 | 0.88 | HTR2A (0.62) | HTR2APTPN7PTPN12PTPN22KMT2A | |
| SCHEMBL30133398 | 0.86 | MEN1 (0.47) | HTR2APTPN7PTPN12PTPN22KMT2A | |
| SCHEMBL25854988 | 0.86 | MEN1 (0.47) | HTR2APTPN7PTPN12PTPN22KMT2A | |
| SCHEMBL29702445 | 0.85 | HTR2A (0.58) | HTR2AHCAR2MAOAMAOBMAPT | |
| SCHEMBL21097197 | 0.85 | HTR2A (0.58) | HTR2AHCAR2MAOAMAOBMAPT | |
| SCHEMBL6400861 | 0.85 | HTR2A (0.61) | HTR2APTPN7PTPN12PTPN22KMT2A | |
| SCHEMBL13736970 | 0.85 | HTR2A (0.58) | HTR2AHCAR2KMT2AMEN1MAOA | |
| SCHEMBL27346757 | 0.85 | HTR2A (0.58) | HTR2APTPN7PTPN12PTPN22KMT2A | |
| SCHEMBL9144432 | 0.84 | HTR2A (0.70) | HTR2APTPN7PTPN12PTPN22KMT2A | |
| SCHEMBL1714950 | 0.84 | HTR2A (0.70) | HTR2AKMT2AMEN1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11040969-B2 | Compounds I | Benevolentai Cambridge Limited (GB) | 2021-06-22 | — | — | US | disclosed |
| US-10399973-B2 | Compounds I | Benevolentai Cambridge Limited (GB) | 2019-09-03 | — | — | US | disclosed |
| US-20180118744-A1 | NEW COMPOUNDS I | PROXIMAGEN LIMITED (GB) | 2018-05-03 | — | — | US | disclosed |
| US-9890160-B2 | Compounds I | PROXIMAGEN LIMITED (GB) | 2018-02-13 | — | — | US | disclosed |
| US-20170044157-A1 | NEW COMPOUNDS I | PROXIMAGEN, LLC | 2017-02-16 | — | — | US | disclosed |
| US-9493457-B2 | 4,5,6,7-tetrahyroimidazo[4,5-c]pyridine compounds | PROXIMAGEN LIMITED (GB) | 2016-11-15 | — | — | US | disclosed |
| US-20150218161-A1 | NEW COMPOUNDS I | PROXIMAGEN, LLC | 2015-08-06 | — | — | US | disclosed |
| US-9035066-B2 | Method of using 4,5,6,7-tetrahydroimidazo[4,5-C]pyridine compounds | PROXIMAGEN LIMITED (GB) | 2015-05-19 | — | — | US | disclosed |
| CN-102232073-B | Ssao activity inhibitor | PROXIMAGEN LTD. (GB) | 2014-10-29 | — | — | CN | disclosed |
| US-20140121219-A1 | New Compounds I | PROXIMAGEN LIMITED (GB) | 2014-05-01 | — | — | US | disclosed |
| EP-2334672-B1 | 4,5,6,7-Tetrahydroimidazo[4,5-c]pyridine compounds as inhibitors of SSAO | PROXIMAGEN LTD (GB) | 2013-11-20 | — | — | EP | disclosed |
| US-8569338-B2 | Methods of using 4, 5, 6, 7-tetrahydroimidazo-[4,5-c]pyridine compounds | PROXIMAGEN LTD. (GB) | 2013-10-29 | — | — | US | disclosed |
| US-20120302583-A1 | New Compounds I | PROXIMAGEN LIMITED (GB) | 2012-11-29 | — | — | US | disclosed |
| US-8263616-B2 | 4,5,6,7-tetrahydroimidazo[4,5-c]pyridine compounds | PROXIMAGEN LTD (GB) | 2012-09-11 | — | — | US | disclosed |
| US-20110207746-A1 | NEW COMPOUNDS I | PROXIMAGEN LIMITED (GB) | 2011-08-25 | — | — | US | disclosed |
| EP-2334672-A1 | NEW COMPOUNDS I | Proximagen Limited (GB) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010031789-A1 | NEW COMPOUNDS I | BIOVITRUM AB (PUBL) (SE) | 2010-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10399973-B2 | Compounds I | SSB, SQLE, ALOX15B | HTR2A 2356/4885PTPN7 2600/4885PTPN12 3321/4885 |
| US-20110207746-A1 | NEW COMPOUNDS I | SSB, NFKBIA, ALOX15B | HTR2A 2068/4885PTPN7 2448/4885PTPN12 3376/4885 |
| US-20120302583-A1 | New Compounds I | SSB, NFKBIA, NOD1 | HTR2A 3202/4885PTPN7 2608/4885PTPN12 3662/4885 |
| US-11040969-B2 | Compounds I | SSB, SQLE, ALOX15B | HTR2A 2356/4885PTPN7 2600/4885PTPN12 3321/4885 |
| US-20140121219-A1 | New Compounds I | SSB, NFKBIA, ALOX15B | HTR2A 2068/4885PTPN7 2448/4885PTPN12 3376/4885 |
| US-20170044157-A1 | NEW COMPOUNDS I | SSB, NFKBIA, ALOX15B | HTR2A 2068/4885PTPN7 2448/4885PTPN12 3376/4885 |
| US-20180118744-A1 | NEW COMPOUNDS I | SSB, NFKBIA, ALOX15B | HTR2A 2068/4885PTPN7 2448/4885PTPN12 3376/4885 |
| US-20150218161-A1 | NEW COMPOUNDS I | SSB, NFKBIA, ALOX15B | HTR2A 2068/4885PTPN7 2448/4885PTPN12 3376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.