Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMKK2 | Q96RR4 | 6/20 | 0.67 |
| ▸ | ABL1 | P00519 | 8/20 | 0.52 |
| ▸ | BCR | P11274 | 7/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.50 |
| ▸ | PRKCA | P17252 | 4/20 | 0.49 |
| ▸ | EGFR | P00533 | 4/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | ITK | Q08881 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30612698 | 0.90 | ABL1 (0.66) | CAMKK2ABL1BCRPDGFRBPDGFRA | |
| SCHEMBL3051385 | 0.90 | ABL1 (0.66) | CAMKK2ABL1BCRPDGFRBPDGFRA | |
| SCHEMBL6599955 | 0.84 | CAMKK2 (0.59) | CAMKK2ABL1BCRPIK3CGGSK3B | |
| SCHEMBL4904288 | 0.83 | CAMKK2 (0.71) | CAMKK2ABL1BCRPIK3CGGSK3B | |
| SCHEMBL30921131 | 0.82 | ABL1 (0.58) | CAMKK2ABL1BCRPDGFRBPDGFRA | |
| SCHEMBL22169842 | 0.77 | CAMKK2 (0.63) | CAMKK2ABL1BCRPIK3CGGSK3B | |
| SCHEMBL6600084 | 0.77 | ABL1 (0.49) | CAMKK2ABL1BCRPIK3CGGSK3B | |
| SCHEMBL2580846 | 0.77 | ABL1 (0.74) | CAMKK2ABL1BCRPIK3CGPDGFRB | |
| SCHEMBL7466961 | 0.76 | SRC (0.63) | CAMKK2ABL1BCRPIK3CGPDGFRB | |
| SCHEMBL7475168 | 0.76 | CCNB2 (0.55) | CAMKK2ABL1BCRPIK3CGGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395261-A2 | PYRIDYLPYRIMIDINE DERIVATIVES AS EFFECTIVE COMPOUNDS AGAINST PRION DISEASES | Axxima Pharmaceuticals Aktiengesellschaft (DE) | 2004-03-10 | — | — | EP | disclosed |
| WO-2002093164-A2 | PYRIDYLPYRIMIDINE DERIVATIVES AS EFFECTIVE COMPOUNDS AGAINST PRION DISEASES | AXXIMA PHARMACEUTICALS AG (DE) | 2002-11-21 | — | — | WO | disclosed |